Porous Cell Administration Device Maintaining Blood Flow
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Solution Overview
Problem
Current cell administration methods for tissue defects, such as skin wounds and vascular defects, face challenges including long culture times for dermal fibroblasts and interruption of blood circulation during cell injection, which are not suitable for large vessels and can be harmful.
Innovation Solution
A device with a biocompatible, cylindrical shape featuring a tight internal wall and a porous external wall, allowing for the administration of healing substances like cell suspensions through a micro-perforated material, and expansion means like a stent to maintain contact with the tissue while allowing blood flow, ensuring effective delivery of cells to defect sites.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cells are administered using an angioplasty balloon catheter with micro needles, then cells can be delivered to the defect site, but blood circulation is interrupted in the vessel during administration
Solution Approach 1:
The device employs a porous wall structure that allows blood to pass through while enabling cell delivery to the defect site. The porous configuration permits simultaneous maintenance of blood circulation and cell administration, eliminating the harmful interruption effect while achieving the therapeutic cell delivery objective
2Reliability
If autologous dermal fibroblasts are cultivated on a biocompatible lattice, then skin wounds or burns can be treated, but long culture time is necessary for the dermal fibroblasts to colonize the lattice prior to implantation
Solution Approach 1:
The device enables preliminary cell preparation without requiring extended culture time for lattice colonization. By using a different administration approach that does not depend on pre-colonization of a lattice structure, the method reduces the time loss while maintaining reliable skin wound treatment efficacy through direct cell delivery to the defect site
3Productivity
If a device with tight internal wall and porous external wall is used, then cells can be delivered efficiently to the defect site, but the device structure becomes more complex
Solution Approach 1:
The porous external wall serves dual functions: it enables efficient cell delivery to the defect site while also allowing blood passage to maintain circulation. This single structural feature addresses multiple requirements, achieving high productivity without proportionally increasing device complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables efficient and minimally invasive delivery of cells to tissue defects, reducing trauma and time required for treatment, while maintaining blood flow and promoting effective wound healing or vascular remodeling.
Implementation Method 1
a porous external wall, allowing for the administration of healing substances like cell suspensions through a micro-perforated material
Implementation Method 2
the cavity being provided between said first and second walls, the healing agent being to be administered through said porous part
Implementation Method 3
expansion means are also provided to bring an outward radial pressure on the internal wall so as to urge said internal wall toward said external wall
Data Source
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AI summary
The present invention relates to a device for cell therapy, said device being designed to be applied on a living tissue and having at least a tight preferably biocompatible first wall, designed to form a cavity between said wall and said tissue, and further comprising means to feed a healing substance in said cavity.