Porous Magnesium Tricalcium Phosphate Bone Repair Composite
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Solution Overview
Problem
Existing bone repair materials, particularly those based on calcium phosphates like hydroxyapatite and tricalcium phosphate, face challenges such as non-degradability, mismatched degradation and osteogenesis rates, and insufficient biological activity, leading to issues like slow bone tissue integration and high production costs.
Innovation Solution
A composite bone repair material composed of collagen and porous magnesium-containing tricalcium phosphate powder, prepared via a low-temperature wet chemical reaction, which forms a micron-sized, low-density powder with a porous structure, enhancing biodegradability and biological activity, and promoting osteogenic differentiation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydroxyapatite is used as bone repair material, then biocompatibility is improved, but degradation rate is reduced (non-degradable)
Solution Approach 1:
The patent changes the chemical composition parameter by incorporating magnesium ions into the tricalcium phosphate crystal structure, creating magnesium-containing tricalcium phosphate with controlled magnesium content (0.1-5 wt%). This parameter change enables the material to maintain biocompatibility while achieving adjustable degradation rates that match bone regeneration speeds, resolving the contradiction between biocompatibility and degradation rate.
Solution Approach 2:
The patent creates a composite material system combining collagen and magnesium-containing tricalcium phosphate in specific ratios (collagen 5-50 wt%, MCTP 50-95 wt%). This composite structure leverages the biocompatibility of collagen and the controlled degradation properties of magnesium-containing tricalcium phosphate, achieving both high biocompatibility and appropriate degradation rate for bone repair.
2Duration of action of moving object
If tricalcium phosphate is used instead of hydroxyapatite, then degradation performance is improved, but production cost increases due to high temperature calcination
Solution Approach 1:
The patent changes the preparation parameter from high-temperature calcination (>900°C) to low-temperature sintering (600-850°C) or wet chemical synthesis methods. This parameter change maintains the degradation performance of tricalcium phosphate while significantly reducing energy consumption and production costs, making the material more economically viable for clinical application.
Solution Approach 2:
The patent replaces the traditional high-temperature thermal processing mechanism with alternative preparation methods including low-temperature sintering and wet chemical synthesis. These alternative mechanisms achieve the same crystalline structure formation and material properties without requiring high-temperature calcination, thereby reducing production costs while maintaining degradation performance.
3Reliability
If collagen and hydroxyapatite are mixed and hot-pressed, then biological activity is improved, but degradation performance worsens (hydroxyapatite is difficult to degrade)
Solution Approach 1:
The patent replaces hydroxyapatite with magnesium-containing tricalcium phosphate in the collagen composite system. The new composite (collagen/MCTP) maintains the biological activity enhancement from collagen while achieving appropriate degradation performance from MCTP, resolving the contradiction between biological activity and degradation performance.
Solution Approach 2:
The patent changes the inorganic component parameter from non-degradable hydroxyapatite to degradable magnesium-containing tricalcium phosphate. This parameter change enables the composite material to exhibit both high biological activity (from collagen) and appropriate degradation performance (from MCTP), solving the degradation issue of traditional collagen/hydroxyapatite composites.
4Strength
If high ceramic phase content is achieved in collagen composite, then mechanical strength is improved, but dispersibility worsens (poor dispersion of hydroxyapatite powder)
Solution Approach 1:
The patent changes the particle size parameter of the ceramic phase to nano-scale (1-100 nm) and optimizes the surface properties of magnesium-containing tricalcium phosphate. These parameter changes enable high ceramic phase content (50-95 wt%) to be achieved while maintaining excellent dispersibility in collagen matrix, as the nano-sized particles have larger surface area and better distribution characteristics compared to larger particles.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The material effectively degrades in vivo, supports new bone tissue growth, and reduces production costs by avoiding high-temperature calcination, while ensuring uniform dispersion and adhesion with collagen, thus overcoming shedding and inflammation issues.
Implementation Method 1
The material effectively degrades in vivo, supports new bone tissue growth
Implementation Method 2
prepared via a low-temperature wet chemical reaction, which forms a micron-sized, low-density powder with a porous structure
Implementation Method 3
The low-density porous powder material produced has good adhesion with polymers such as collagen
Data Source
AI summary
Discloses are an artificial bone repair material and a preparation method therefor, and a preparation method for a porous magnesium-containing tricalcium phosphate powder for an artificial bone repair material. The artificial bone repair material is a composite material with a porous structure. Raw materials of the artificial bone repair material includes collagen; and porous magnesium-containing tricalcium phosphate powder formed by a precipitate after reaction of calcium salt, magnesium salt and phosphate solution through spray drying, and a particle size of the porous magnesium-containing tricalcium phosphate powder is 1-20 μm. A mass percentage of the porous magnesium-containing tricalcium phosphate to the artificial bone repair material is 50-95%.