Porous Matrix and Bead Device for Simultaneous Body Fluid Separation
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Solution Overview
Problem
Current devices for binding and separating components from body fluids, such as those used in sepsis treatment, face challenges in efficiently removing multiple inflammatory mediators like LPS, LTA, and cytokines without causing channeling or reducing adsorption capacity, and often require multiple separation steps.
Innovation Solution
A device comprising a housing with a porous first matrix sheet or disc for distributing body fluid and beads of a second matrix for binding components, allowing simultaneous binding and separation of multiple components, including LPS, LTA, and cytokines, through adsorption, hydrophobic, hydrophilic, and ionic interactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a single separation matrix is used for binding multiple components, then the device complexity is reduced and productivity is improved, but the adsorption capacity for each individual component may be insufficient
Solution Approach 1:
The separation matrix is divided into multiple functional layers, with each layer containing beads specific to binding particular components (e.g., LPS, LTA, cytokines). This segmentation allows each layer to specialize in binding its target components, thereby maintaining high adsorption capacity for each component while enabling simultaneous separation of multiple components in a single device.
Solution Approach 2:
The device achieves multi-functionality by integrating multiple specialized binding layers into a single separation matrix. Each layer performs a specific binding function, and together they provide universal capability to separate multiple different components (LPS, LTA, various cytokines) simultaneously, thus improving productivity without sacrificing individual adsorption capacities.
2Quantity of substance
If multiple separation steps are used to remove different inflammatory mediators, then the adsorption capacity for each component is maximized, but the device complexity increases and treatment time is extended
Solution Approach 1:
Multiple separation steps are merged into a single integrated separation matrix. Different functional layers targeting various inflammatory mediators (LPS, LTA, cytokines) are combined in one device, allowing simultaneous removal of multiple components in a single passage. This merging reduces device complexity and treatment time while preserving the adsorption capacity of each individual layer through specialized bead composition.
3Ease of operation
If porous structure is used in the separation matrix, then blood cell passage is enabled, but channeling may occur reducing adsorption efficiency
Solution Approach 1:
The porous structure is applied locally and selectively in different regions of the separation matrix. The porous layers are positioned to allow blood cell passage while maintaining controlled flow distribution. This local quality approach enables blood cells to pass through without causing channeling that would reduce adsorption efficiency, as the porous structure is optimized to balance flow distribution with adsorption capacity in each specific region.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively binds and separates inflammatory mediators from whole blood, preventing channeling and maximizing adsorption capacity, enabling efficient treatment of sepsis by removing both the cause and endogenous mediators of inflammation, thus mitigating multiorgan dysfunction.
Implementation Method 1
beads of a second matrix for binding components, allowing simultaneous binding and separation of multiple components, including LPS, LTA, and cytokines, through adsorption, hydrophobic, hydrophilic, and ionic interactions
Data Source
AI summary
A device for binding and separation of at least one component from a body fluid is disclosed. The device may have a proximal end and a distal end. The device may include a housing, an inlet disposed at the proximal end, an outlet, at least one of a sheet and a disc of a first matrix for binding of a first component from the body fluid, and a plurality of beads of a second matrix for binding of a second component from the body fluid. The first matrix may have a porous structure. The first component and the second component may be one of the same and different.