Porous Polymer Virus Collection Matrix for Rapid Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for detecting and managing virus infections, such as COVID-19, are time-consuming, costly, and difficult to implement universally, necessitating a more efficient and cost-effective means for early warning and risk management.
Innovation Solution
A virus collection matrix comprising a porous gel or fibrous structure made of positively charged polymer material with distributed ACE 2 receptors, which captures and detects target viruses like COVID-19 through electrostatic attraction and chemical grafting, enabling qualitative analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If quantitative detection methods such as nucleic acid amplification testing and antibody detection are used, then detection accuracy is improved, but time consumption, cost, and complexity increase significantly
Solution Approach 1:
The patent extracts the essential detection function from complex quantitative methods by using a simplified matrix-based approach. The virus collection matrix with ACE2 receptors directly captures viral particles through electrostatic attraction and specific receptor binding, eliminating the need for time-consuming nucleic acid amplification or antibody detection procedures while maintaining detection capability
Solution Approach 2:
The patent creates a simplified model system using a virus collection matrix that mimics the function of complex detection systems. The matrix with ACE2 receptors serves as a surrogate for direct viral detection, allowing rapid assessment of viral presence without replicating the complex biochemical processes of traditional quantitative methods
2Measurement precision
If quantitative detection methods such as nucleic acid amplification testing and antibody detection are used, then detection accuracy is improved, but cost increases significantly
Solution Approach 1:
The patent employs a disposable virus collection matrix that can be manufactured at low cost using simple materials like chitosan and electrospun fibers. This single-use matrix eliminates the need for expensive reagents, equipment, and personnel training required for traditional quantitative detection methods, making the technology economically viable for widespread deployment
Solution Approach 2:
The patent extracts the essential detection function from expensive complex detection systems by using a simplified matrix-based approach that relies on fundamental physical and biological principles (electrostatic attraction and receptor-ligand binding) rather than costly biochemical reagents and specialized equipment
3Difficulty of detecting and measuring
If complex detection systems are implemented, then detection capability is improved, but ease of operation and universal applicability worsen
Solution Approach 1:
The virus collection matrix performs detection functions automatically through its inherent properties - the electrostatically charged chitosan structure and embedded ACE2 receptors spontaneously capture viral particles from the environment without requiring complex operational procedures. The matrix essentially detects viruses for itself, eliminating the need for skilled operators and complex equipment
Solution Approach 2:
The patent creates a universal detection platform that can detect various viruses containing spike proteins through the common mechanism of ACE2 receptor binding. The same matrix design and operational procedure can be applied across different viral targets, making the system universally applicable and easy to operate without requiring virus-specific customization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The matrix allows for rapid, cost-effective collection and detection of viruses in environments, supporting early warning and risk management systems by increasing sensitivity and reducing the spread of infections.
Implementation Method 1
A virus collection matrix, a manufacturing method of the virus collection matrix, and a detection method for detecting a target virus provided by each embodiment of the present disclosure are applicable to the collection of virus in the environment
Implementation Method 2
distributing and covering a plurality of ACE 2 receptors on a surface of the porous gel or fibrous structure, and connecting the plurality of ACE 2 receptors to the porous gel or fibrous structure by electric charge attraction or chemical grafting
Data Source
AI summary
The present invention provides a virus collection matrix, including: a porous gel or fibrous structure formed by a positively charged polymer material; and a plurality of ACE 2 receptors. The plurality of ACE 2 receptors are negatively charged, and distributed and covered on the surface of the porous gel or fibrous structure. The whole virus collection matrix is positively charged.