Porous Tip Activation for Olefin Tissue Adhesive Polymerization
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Solution Overview
Problem
Existing devices and methods for dispensing olefin-based tissue adhesives face challenges in achieving complete and consistent polymerization, leading to issues such as incomplete polymerization, cytotoxicity, and poor adhesion, due to the inherent reactivity differences between olefins and cyanoacrylates.
Innovation Solution
A device and method utilizing a porous element with an activator solution arranged in a discontinuous geometrically symmetrical pattern to activate electron-deficient olefin-based monomers, ensuring controlled polymerization on dry or wet tissue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional activator placement on UHMWPE filter is used for olefin-based monomers, then activation occurs, but incomplete polymerization results leading to cytotoxicity and poor adhesion
Solution Approach 1:
The patent changes the chemical parameters of the activator system by using a solution containing multiple activators (e.g., triethylamine and boronic acid compounds) instead of simple salts. This parameter change enables complete polymerization of olefin-based monomers, eliminating cytotoxicity while maintaining ease of application.
2Ease of operation
If activator is placed on porous element surface, then activation is simplified, but inconsistent polymerization occurs leading to variable film properties
Solution Approach 1:
The patent utilizes a porous element (such as a porous filter or sponge) as the activator carrier. The porous structure allows the activator solution to be distributed throughout the material, ensuring consistent contact with the monomer and producing uniform polymerization and film properties while maintaining ease of application.
3Ease of manufacture
If olefin-based monomers are used instead of cyanoacrylates, then better cosmetic output is achieved, but lower reactivity requires different activation methods
Solution Approach 1:
The patent introduces a porous element as an intermediary carrier that holds the activator solution. This intermediary facilitates the activation process by ensuring controlled release and consistent contact between the activator and olefin-based monomer, simplifying the overall activation method while achieving the desired cosmetic results.
4Reliability
If activator solution is used instead of solid activator, then better monomer activation is achieved, but control of activation timing and location becomes difficult
Solution Approach 1:
The patent employs a porous element to contain and deliver the activator solution. The porous structure provides capillary action and controlled release, maintaining activation efficiency while improving control over when and where activation occurs. The porous carrier allows the solution to be applied conveniently while preventing premature activation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves reproducible and efficient activation of olefin-based monomers, resulting in consistent film formation with improved adhesion and mechanical properties, overcoming the limitations of prior art.
Implementation Method 1
The porous element allows the monomeric and/or polymeric composition to pass therethrough and activate the electron-deficient olefin-based monomer to initiate polymerization
Implementation Method 2
activate the electron-deficient olefin-based monomer to initiate polymerization
Data Source
Figure 1~2
Figure 3~4H
AI summary
The present invention provides a device for dispensing a tissue adhesive, said device comprising an outer body made of a flexible material, a monomeric and/or polymeric composition arranged inside said outer body, an applicator tip removably attached to said outer body and at least one porous element comprised inside the applicator tip and having an activator solution arranged thereon and/or therein. The present invention also provides a method for activating electron-deficient olefin monomers, such as methylene malonate monomers. The method comprises providing a monomer formulation comprising at least one electron-deficient olefin monomer; providing at least one porous element having an activator solution therein; and forcing, at least once, the monomer formulation through the at least one porous element to contact the activator solution.