Portable Allergy Detection System Using Filtration-Based FPW Sensor
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Solution Overview
Problem
Conventional ELISA analysis for immunoglobulin concentration is compromised by heating and centrifugation processes, leading to reduced accuracy and high costs, with lengthy examination procedures that hinder immediate detection of allergic diseases.
Innovation Solution
A portable detection system incorporating a filtration-based inspection module with an FPW sensor and liquid sample filtration apparatus, which separates blood serum from whole blood, enabling rapid immunoglobulin concentration measurement using AC signals and reducing sample volume and detection time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If ELISA analysis uses heating and centrifugation processes, then sample preparation is achieved, but accuracy of immunoglobulin concentration is reduced and sample is damaged
Solution Approach 1:
The patent extracts and removes the harmful heating and centrifugation steps from the ELISA analysis procedure. Instead of using these aggressive sample preparation methods, the invention employs a filtration-based approach that separates blood components gently, preserving the integrity and antigenicity of the sample while still achieving effective sample preparation for accurate immunoglobulin concentration measurement.
Solution Approach 2:
The patent replaces the mechanical heating and centrifugation system with a filtration-based inspection module. This substitution eliminates the need for thermal and high-speed mechanical processing, using instead a passive or low-energy filtration mechanism that achieves sample separation without damaging the immunoglobulins or other sample components.
2Reliability
If conventional ELISA analyzer uses huge amount of reagent, then detection is performed, but examination expenses for patient burden are relatively expensive
Solution Approach 1:
The patent changes the parameters of the detection system by using a portable FPW sensor-based platform that requires significantly less reagent volume compared to conventional ELISA analyzers. The filtration-based inspection module and sensor design enable effective detection with minimal reagent consumption, thereby reducing examination expenses while maintaining reliable detection capability for immunoglobulin concentration.
3Measurement precision
If conventional ELISA examination procedure takes 7 to 10 days, then complete analysis is achieved, but patient suffering from allergic disease can not proceed with immediate detection
Solution Approach 1:
The patent implements preliminary action by using a filtration-based inspection module that rapidly separates blood components and prepares the sample for detection in minutes rather than days. This preliminary filtration step eliminates the need for lengthy incubation and multiple processing steps required by conventional ELISA, enabling immediate detection of immunoglobulin concentration while maintaining analysis completeness through the portable FPW sensor system.
4Productivity
If portable detection system uses filtration-based inspection module, then detection time is reduced and sample volume is minimized, but device complexity increases
Solution Approach 1:
The patent merges the filtration function and inspection/detection function into a single integrated filtration-based inspection module. The liquid sample filtration apparatus is directly coupled with the portable FPW sensor, combining sample preparation and measurement capabilities in one compact unit. This integration reduces overall device complexity compared to having separate filtration and detection systems, while achieving rapid detection with minimal sample volume.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system allows for immediate and accurate detection of immunoglobulin concentration in human serum, offering a compact, cost-effective solution with reduced sample volume and time, suitable for preliminary diagnosis of allergic diseases.
Implementation Method 1
a liquid sample filtration apparatus, wherein the liquid sample filtration apparatus includes an injection opening, a passage module, a filtering membrane and a gathering aperture
Implementation Method 2
The FPW sensor enables to output a first AC signal contained with information of immunoglobulin concentration for blood serum and a second AC signal
Data Source
AI summary
A portable detection system for allergic diseases includes a filtration-based inspection module and a reader module. The filtration-based inspection module includes an FPW sensor and a liquid sample filtration apparatus, wherein the liquid sample filtration apparatus includes an injection opening, a passage module, a filtering membrane and a gathering aperture. The injection opening is in communication with the gathering aperture. The FPW sensor comprises a frame body, a carrier and a sensing chip having an accommodating slot in communication with the gathering aperture. The carrier comprises a plurality of conductive terminals, and the conductive terminals are electrically connected with the sensing chip. The reader module comprises a connection slot capable of being inserted by the conductive terminals of the carrier.