Portable Blood Processing System with Alternating Component Delivery
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Solution Overview
Problem
Conventional blood processing systems are cumbersome, difficult to transport, and lack advanced automation for efficient separation and collection of blood components, particularly in complex and portable applications, where detailed control and data generation are needed.
Innovation Solution
A portable blood processing system with a programmable blood processing circuit and a controller that alternates between conveying red blood cells and plasma, using a pump system and separation device to optimize the separation and collection process, and includes a disposable flow set for sterile operation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional blood centrifuges are used for separating blood components, then separation efficiency is improved, but device size and portability deteriorate
Solution Approach 1:
The blood processing system is divided into separate functional modules: a portable centrifuge unit for separation and a transfusion unit for controlled delivery. This segmentation allows the centrifuge to be optimized for separation efficiency while the transfusion unit handles precise component delivery, reducing the need for a single large integrated device.
Solution Approach 2:
A controller acts as an intermediary between the centrifuge and the transfusion system, managing the coordination of blood component separation and subsequent controlled delivery. This intermediary control enables optimized separation processes while maintaining precise control over component transfusion, decoupling the size requirements of separation and delivery functions.
2Ease of operation
If conventional loading and unloading operations are used, then operational simplicity is maintained, but time consumption and tediousness increase
Solution Approach 1:
The system pre-positions and pre-configures blood collection bags and transfusion components before actual blood processing begins. The controller pre-programmes the sequence of operations including loading, separation, and transfusion steps, reducing manual intervention and time consumption during critical phases of the procedure.
3Device complexity
If basic blood component collection is performed, then operational complexity is reduced, but control precision and data generation capabilities deteriorate
Solution Approach 1:
The controller continuously monitors blood component separation progress and transfusion delivery, using sensors to detect volume, flow rate, and component composition. This feedback information is used to automatically adjust pumping rates and separation parameters, maintaining high precision control while the controller manages the complexity of these adjustments.
Solution Approach 2:
The system automatically controls the pumping and transfusion processes based on pre-programmed protocols and real-time sensor feedback, reducing the need for manual intervention. The controller self-regulates the complexity of coordinated operations between centrifuge and transfusion unit, providing precise control without requiring complex manual operations.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables efficient and automated processing of blood components, improving transportability and operational efficiency by providing detailed control and data for maximizing separation and collection efficiencies in various applications.
Implementation Method 1
separate whole blood, usually by centrifugation, into its various therapeutic components
Implementation Method 2
a pump system and a controller programmed to actuate the pump system to convey blood from a blood source into the separation device
Data Source
AI summary
Systems and methods are provided for conveying an amount of red blood cells and an amount of plasma to a blood source. Blood is conveyed from a blood source into a separation device and the separation device is operated to separate the blood into a layer containing red blood cells and a layer containing plasma. Red blood cells and plasma are removed from the separation device and volumes of the red blood cells and plasma are conveyed to the blood source. The volumes of red blood cells and plasma are alternately conveyed to the blood source for said amounts of red blood cells and plasma.