Portable Coagulation Monitor With Capillary Blood Introduction
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for blood coagulation monitoring, particularly in point-of-care settings, face challenges in ensuring sterility and efficiency in blood introduction and require complex pipetting processes, which are cumbersome and impractical for rapid assessment of coagulation response in trauma patients.
Innovation Solution
A portable coagulation monitoring device utilizing glass-filled thermoplastic polymer plates with optical detection, enabling rapid coagulation response measurement through linear motion of the plates and optical detection of light interaction with blood samples, accompanied by a disposable blood introduction mechanism for precise blood dosing without manual measurement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If manual pipetting processes are used for blood introduction, then blood dosing can be performed, but the process becomes complex and cumbersome
Solution Approach 1:
The device enables self-service blood introduction through capillary action. The blood sample automatically flows into the measurement chamber via capillary forces without requiring manual pipetting or external intervention, thereby simplifying the operation while maintaining dosing accuracy
Solution Approach 2:
The complex manual pipetting process is extracted and replaced by an integrated capillary blood introduction system. The blood introduction mechanism is taken out as a separate functional component that automatically performs dosing through capillary action, eliminating the need for external pipettes or syringes
2Reliability
If manual blood handling is used, then blood can be introduced to the device, but sterility assurance becomes difficult
Solution Approach 1:
The blood introduction system uses a disposable capillary blood introduction component that is pre-sterilized and single-use. This ensures sterility assurance while maintaining ease of operation, as the disposable nature eliminates sterilization concerns and simplifies the handling process for each test
Solution Approach 2:
Sterility is ensured through preliminary action by pre-sterilizing the capillary blood introduction component during manufacturing. The component arrives ready-to-use in a sterile state, eliminating the need for on-site sterilization procedures and simplifying the blood handling process
3Productivity
If rapid coagulation assessment is performed, then treatment time is reduced, but measurement accuracy may be compromised
Solution Approach 1:
The device replaces traditional mechanical timing and visual assessment methods with an optical detection system. Light interaction changes are automatically measured and analyzed, providing both rapid assessment and precise measurement of coagulation responses through objective optical parameters
Solution Approach 2:
The system monitors multiple parameter changes during coagulation including light transmission, absorption, and scattering properties. By tracking these optical parameter changes over time, the device achieves both rapid assessment and high measurement precision through multi-parameter analysis
Data Source
AI summary
Portable coagulation monitoring devices, systems, and methods are disclosed. Namely, a test cartridge is provided for use in a portable coagulation monitor (PCM) device. Further, the test cartridge comprises two glass-filled thermoplastic polymer plates and a disposable blood introduction device. The two glass-filled thermoplastic polymer plates are arranged substantially in parallel with a small gap therebetween for receiving a sample of blood to be tested. Using the PCM device, the two glass-filled thermoplastic polymer plates can be moved linearly relative to each other. Methods of measuring coagulation response in a blood sample using the test cartridge and the PCM device are provided. A method of introducing blood into the test cartridge using the disposable blood introduction device is provided.