Portable Genome Sequencing Device Integrating Local Genotyping Analysis

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Solution Overview

Problem

Current genome sequencing devices require multiple steps on different devices and necessitate cloud-based data upload for genotyping analysis due to memory computing resource constraints, limiting portability and efficiency.

Innovation Solution

A portable genome sequencing and genotyping device comprising a sample processing module, sequencing module, analyzing module, and communication module that processes DNA samples, generates base sequences, performs genotyping analysis, and transmits results to a user terminal, enabling local computation and data transmission without cloud dependency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If genome sequencing is performed using current devices, then sequencing function is achieved, but the device requires multiple separate devices and cloud upload for complete analysis

Engineering Contradiction:

Improvegenome sequencing and genotyping functionalityVSAvoidnumber of devices required

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent combines sample processing module, sequencing module, analyzing module, and communication module into a single integrated portable device. This merging eliminates the need for multiple separate devices and cloud upload, allowing complete genome sequencing and genotyping analysis to be performed locally on one device.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The portable device performs multiple functions including sample processing, DNA sequencing, genotyping analysis, and result transmission within a single system. This multi-functionality replaces the need for separate specialized devices and cloud-based analysis platforms.

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Measurement precision

If genotyping analysis is performed on current devices, then analysis is completed, but data must be uploaded to cloud due to memory computing resource constraints

Engineering Contradiction:

Improvegenotyping analysis accuracyVSAvoidmemory computing resources

Core Design Contradiction:

Measurement precisionVSQuantity of substance

Solution Approach 1:

The patent changes the parameter of computing resource capacity by equipping the portable device with sufficient local memory and processing power to perform genotyping analysis without cloud dependency. This parameter change enables complete local analysis while maintaining accuracy.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If cloud upload is used for genotyping analysis, then analysis capability is achieved, but portability is limited

Engineering Contradiction:

Improvegenotyping analysis capabilityVSAvoidportability

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent merges the analyzing module directly into the portable device, combining sequencing and analysis capabilities in one unit. This eliminates the separate cloud upload step and enables complete portability while maintaining full genotyping analysis capability.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS11840729B2Portable genome sequencing and genotyping device and operating method thereof

Publication Date: 2023.12.12 NAT CHIAO TUNG UNIV

AI summary

A portable genome sequencing and genotyping device includes a sample processing module, a sequencing module, an analyzing module, and a communication module. The sample processing module is configured to process a sample so as to generate at least one DNA segment of the sample. The sequencing module is connected to the sample processing module, and is configured to generate a number of base sequences corresponding to the at least one DNA segment. The analyzing module is coupled to the sequencing module, and is configured to generate a genotyping analysis result based on the base sequences. The communication module is configured to receive the genotyping analysis result and transmit the genotyping analysis result to a user terminal.