Postbiotic Extract Preparation for Skin Regeneration
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Solution Overview
Problem
Current methods for improving skin condition, such as anti-aging cosmeceuticals, are inadequate in completely eliminating wrinkles and enhancing skin repair, often requiring multiple and expensive treatments.
Innovation Solution
A method involving the preparation of a postbiotic extract by combining a probiotic microorganism with materials of specific isoelectric points, followed by pH adjustment and cell wall extraction, to create a precipitate that is then treated to obtain a postbiotic extract for topical application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple anti-aging treatments are used to improve skin condition, then skin regeneration and wrinkle elimination are enhanced, but treatment cost and complexity increase
Solution Approach 1:
The patent combines multiple beneficial components (probiotic microorganisms, first material with isoelectric point pH 1-6, second material with isoelectric point pH 4-8) into a single postbiotic extract formulation. This merging approach integrates multiple functions (skin regeneration, wrinkle reduction, safety) into one treatment, eliminating the need for multiple separate treatments while maintaining effectiveness.
Solution Approach 2:
The postbiotic extract serves multiple functions simultaneously: it promotes skin regeneration through TGF-β secretion, reduces wrinkles, ensures safety through non-viable microorganisms, and provides cost-effectiveness. This multi-functionality resolves the contradiction by making one treatment replace multiple specialized treatments.
2Reliability
If live probiotic microorganisms are used to improve skin condition, then intestinal microflora balance is restored, but stability and viability during storage are compromised
Solution Approach 1:
Instead of using live probiotic microorganisms, the patent inverts the approach by using non-viable (killed) microorganisms that have been processed to release their beneficial components. This inversion maintains the health benefits through postbiotics while eliminating the stability and viability issues associated with live organisms during storage and application.
Solution Approach 2:
The patent extracts the beneficial components (postbiotics) from the microorganisms by subjecting them to processing steps including pH adjustment and cell wall extraction. This extraction separates the active beneficial substances from the need for viable organisms, allowing stable storage and application without compromising health benefits.
3Reliability
If growth factors are incorporated into cosmeceuticals to stimulate collagen production, then wound healing and skin repair are improved, but safety and regulatory concerns arise
Solution Approach 1:
The patent uses non-viable probiotic microorganisms as intermediaries to indirectly stimulate collagen production and wound healing. Instead of directly applying growth factors (which raise safety concerns), the microorganisms serve as mediators that naturally induce the body's own growth factor secretion, thereby achieving the same therapeutic effect with improved safety and regulatory acceptance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The postbiotic extract effectively induces TGF-β secretion and improves skin cell proliferation, promoting skin regeneration and enhancing skin quality, thus addressing the limitations of existing treatments.
Implementation Method 1
adding the second material into the mixture, followed by adjusting a pH value of the second material-added mixture to between the first isoelectric point and the second isoelectric point, so that a precipitate is formed
Data Source
AI summary
A method for improving skin condition includes administering to a subject in need thereof a postbiotic extract. The postbiotic extract is prepared by a process including the steps of providing a first material having a first isoelectric point ranging from pH 1 to pH 6 and a second material having a second isoelectric point ranging from pH 4 to pH 8, admixing the first material and a probiotic microorganism with water having a pH greater than the second isoelectric point, so as to forma mixture, adding the second material into the mixture and then adjusting a pH of the second material-added mixture to between the first and second isoelectric points so that a precipitate is formed, and subjecting the precipitate to a cell wall isolation treatment to obtain the postbiotic extract.