Post-biotic Skin Compositions for Microbiome Rebalancing

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Solution Overview

Problem

Current skin care products are inadequate in maintaining skin elasticity and firmness, and they face challenges in effectively rebalancing the skin microbiome to inhibit harmful bacteria while promoting beneficial bacteria.

Innovation Solution

The development of post-biotic compositions containing saccharide isomerate and a short-chain fatty acid blend, including lactic acid and other short-chain fatty acids, which are incorporated into personal care compositions to rebalance the skin microbiome.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If probiotics are used to rebalance skin microbiome, then beneficial bacteria growth is promoted, but the ability to simultaneously inhibit harmful bacteria remains challenging

Engineering Contradiction:
Improvemicrobiome rebalancing effectivenessVSAvoiddual-action mechanism complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines probiotics with post-biotic components (short-chain fatty acids, saccharide isomerate, and other metabolites) into a single composition. This merging allows the formulation to simultaneously promote beneficial bacteria growth through probiotics while inhibiting harmful bacteria through the antimicrobial properties of post-biotics, resolving the challenge of achieving dual action without increased complexity

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite personal care composition that integrates multiple functional components: live probiotics, short-chain fatty acids (lactic acid, acetic acid, propionic acid), saccharide isomerate, and other metabolites. This composite approach enables the single formulation to deliver both beneficial bacteria promotion and harmful bacteria inhibition through the synergistic interaction of its components

Inventive Principle:
Principle #40Composite materials

2Ease of operation

If current skin care products are used, then basic skin care functions are provided, but skin elasticity and firmness maintenance is inadequate

Engineering Contradiction:
Improveskin care functionalityVSAvoidskin elasticity and firmness maintenance
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent introduces specific biochemical parameters to personal care compositions, including short-chain fatty acids (particularly lactic acid at 0.1-10%), saccharide isomerate (0.1-10%), and other probiotic metabolites. These parameter changes target skin elasticity and firmness maintenance by providing building blocks for collagen synthesis and skin barrier repair, going beyond basic skin care functions

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The probiotics and post-biotics act as intermediaries between the personal care composition and skin tissue. These microorganisms and their metabolites mediate the delivery of beneficial compounds to the skin, promoting collagen production, enhancing skin barrier function, and improving elasticity and firmness through biological pathways rather than direct chemical action

Inventive Principle:
Principle #24Intermediary (Mediator)

Data Source

PatentUS20250195382A1Personal Care Compositions
Publication Date: 2025.06.19 COLGATE PALMOLIVE CO
  • US20250195382A1 patent drawing
  • US20250195382A1 patent drawing

AI summary

Described herein are post-biotic compositions and personal care compositions thereof for rebalancing skin microbiome and personal care compositions containing the same. In accordance with an aspect of the invention, provided is a post-biotic composition comprising saccharide isomerate; and a short-chain fatty acid blend comprising at least two short-chain fatty acids and/or a salt thereof, wherein the short-chain fatty acid blend comprises lactic acid and/or a salt thereof.