Postbiotic Composition for Weight Loss via Propionibacterium freudenreichii

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Solution Overview

Problem

Obesity is a growing health concern in the Western world, with increasing prevalence and associated negative health effects such as type 2 diabetes, heart disease, and certain cancers, for which existing compositions and methods for weight loss are not sufficiently effective.

Innovation Solution

The use of compositions comprising a postbiotic derived from Propionibacterium freudenreichii UF (UF1) for reducing body weight, body fat, and preventing obesity, which can be administered alone or in combination with other therapeutic agents or procedures such as gastric bypass surgery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing compositions and methods are used for weight loss, then some weight reduction may be achieved, but the effectiveness is insufficient for addressing the growing obesity epidemic

Engineering Contradiction:

Improveeffectiveness of weight lossVSAvoidrate of weight loss

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent changes the biological parameter by introducing a specific probiotic strain (Propionibacterium freudenreichii UF1) with unique characteristics that enhance weight loss effectiveness. This strain produces specific metabolites and interacts with host metabolism in ways that existing compositions do not, thereby improving both reliability and productivity of weight loss outcomes

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite biological system by combining the probiotic P. freudenreichii UF1 with specific prebiotics and other therapeutic agents. This composite approach synergistically enhances weight loss effectiveness beyond what single agents can achieve, addressing the insufficiency of existing treatments

Inventive Principle:

Principle #40Composite materials

2Productivity

If aggressive weight loss methods are used, then faster weight reduction may be achieved, but health risks and side effects increase

Engineering Contradiction:

Improverate of weight lossVSAvoidhealth risks

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the potential harm of rapid weight loss into benefit by using a probiotic that naturally regulates metabolism. The P. freudenreichii UF1 strain produces metabolites that promote sustainable fat oxidation and improve insulin sensitivity, achieving effective weight loss while simultaneously reducing health risks associated with aggressive methods

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The probiotic acts as a biological intermediary that mediates between dietary intake and energy expenditure. It produces signaling molecules and metabolites that gently regulate host metabolism, enabling effective weight loss without the harsh effects of extreme diets or medications

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS20250195585A1Postbiotic compositions and methods and use therof

Publication Date: 2025.06.19 SCHISM BIOWORKS LLC

AI summary

Disclosed herein are number embodiments relating to technologies for the use of postbiotic materials for the improvement of health. In certain embodiments, the composition is a postbiotic derived from at least one strain of bacteria wherein the at least one strain of bacteria comprises Propionibacterium freudenreichii UF (UF1). In certain specific embodiments contained in this disclosure, the postbiotic materials can lead to an reduction in body weight and an increase the portion of weight lost from fat rather than lean body mass.