Posterior Mitral Valve Positioning for Better LV Flow
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Solution Overview
Problem
Current transcatheter mitral valve replacement and repair technologies produce imperfect outcomes, and open-heart surgery carries substantial side effects, failing to improve or often deteriorating left ventricular function.
Innovation Solution
A delivery device is used to advance a prosthetic mitral valve with a valve frame off-center and angled toward the posterior side of the annular plane, anchoring to native mitral valve leaflets via rotating arms that recruit chords, allowing radial expansion to trap the leaflets and optimize blood flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If current transcatheter mitral valve replacement and repair technologies are used, then minimally invasive procedure is achieved, but left ventricular function deteriorates and outcomes are imperfect
Solution Approach 1:
The prosthetic mitral valve is deliberately positioned off-center relative to the mitral annulus, with the valve frame centered on the coaptation line rather than the geometric center. This asymmetric positioning aligns the valve with the native anatomy of the mitral leaflet coaptation, optimizing blood flow dynamics and left ventricular function while maintaining the minimally invasive transcatheter approach
2Reliability
If open-heart surgery is performed to replace mitral valve, then valve replacement is achieved, but substantial side effects occur and left ventricular function does not improve
Solution Approach 1:
The patent replaces the mechanical open-heart surgical system with a transcatheter delivery system that navigates through the vascular system. The prosthetic valve is delivered via a catheter through the femoral vein and deployed in the left atrium, eliminating the need for sternotomy, cardiopulmonary bypass, and direct surgical manipulation of the heart, thereby avoiding substantial surgical side effects
3Ease of manufacture
If prosthetic mitral valve is positioned at center of annular plane, then standard implantation is achieved, but blood flow efficiency is suboptimal and coaptation is imperfect
Solution Approach 1:
The patent applies local quality by positioning the prosthetic valve specifically at the coaptation line of the native mitral leaflets rather than at the geometric center of the annulus. This localized positioning optimizes the interaction between the prosthetic valve and native anatomy, improving blood flow efficiency and coaptation quality in the specific region where leaflet convergence occurs
Data Source
AI summary
Apparatus and methods are described including a delivery device that delivers a valve frame to a native valve and positions the valve frame such that a center of the valve frame is off center with respect to a center of an annular plane of the valve annulus, and is positioned toward a posterior side of the annular plane. Arms of the valve frame are deployed among the chords of the native valve. The valve frame is rotated, such as to cause the arms to pull the leaflets of the native valve radially inwards. A frame body of the valve frame radially expands, such as to trap the native valve leaflets, and such that the valve frame is deployed off center with respect to the center of the annular plane. Other applications are also described.