Plasma Protein Fraction for Postoperative Pain and Wound Healing

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Solution Overview

Problem

Current treatments for postoperative recovery, including pain management and wound healing, are inadequate, with multimodal interventions being time-consuming and lacking a single effective technique, and existing analgesics often leading to addiction and mortality issues.

Innovation Solution

The use of blood plasma fractions, such as Plasma Protein Fraction (PPF), derived from blood fractionation processes, to treat symptoms and conditions associated with surgical recovery, including pain and wound healing, by administering these fractions preoperatively, perioperatively, or postoperatively to accelerate recovery and reduce complications.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If multimodal interventions are used for postoperative recovery, then comprehensive care is provided, but treatment time and resource consumption increase

Engineering Contradiction:

Improvecomprehensive careVSAvoidtreatment time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent combines multiple therapeutic functions (analgesia, anti-inflammatory effects, wound healing promotion) into a single blood plasma fraction product, eliminating the need for multiple separate interventions while providing comprehensive postoperative care

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Blood plasma fractions are demonstrated to have multiple therapeutic effects simultaneously - pain relief, inflammation reduction, and wound healing acceleration - making a single intervention that addresses multiple postoperative complications

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Object-affected harmful factors

If traditional analgesics are used for pain management, then pain relief is achieved, but addiction and mortality risks increase

Engineering Contradiction:

ImprovepainVSAvoidaddiction and mortality

Core Design Contradiction:

Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

Blood plasma fractions serve as a natural intermediary substance that provides analgesia through endogenous mechanisms rather than exogenous opioid drugs, eliminating addiction risks while maintaining pain relief efficacy

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent utilizes blood plasma, a naturally occurring biological fluid that can be safely administered and metabolized without accumulating toxic effects or creating dependency, replacing long-acting opioid medications

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If surgery is performed, then medical treatment is provided, but postsurgical complications and extended recovery time occur

Engineering Contradiction:

Improvemedical treatmentVSAvoidrecovery time

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

Blood plasma fractions can be administered preoperatively to prepare the patient's physiological systems for surgery, reducing the surgical stress response and priming wound healing mechanisms before the surgical trauma occurs

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent describes administering blood plasma fractions across multiple time points (preoperatively, intraoperatively, and postoperatively) to maintain continuous therapeutic support throughout the entire recovery process, accelerating each phase of healing

Inventive Principle:

Principle #20Continuity of useful action

Data Source

PatentUS20230285455A1Use of Plasma and Plasma Fractions for Improvement of Pain, Wound Healing, and Postoperative Recovery

Publication Date: 2023.09.14 ALKAHEST INC

AI summary

Methods and compositions for improving postoperative recovery are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing conditions associated with postoperative recovery.