Pre-Adapted Bacterial Consortium for Gut Microbiome Stability

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Solution Overview

Problem

Current treatments for gastrointestinal disorders, such as dysbiosis, are inadequate as they often fail to effectively restore the balance of the gut microbiome, leading to complications like diarrhea, IBS, IBD, and other health issues, and existing mixtures of bacterial species may not interact optimally or be stable enough for therapeutic use.

Innovation Solution

A composition of pre-adapted bacterial species, including Faecalibacterium prausnitzii, Butyricicoccus pullicaecorum, Roseburia inulinivorans, Roseburia hominis, Akkermansia muciniphila, Lactobacillus plantarum, and Anaerostipes caccae, grown together in a fermenter to enhance their interaction and functionality, is administered to treat or prevent gastrointestinal disorders.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing mixtures of bacterial species are used to treat gastrointestinal disorders, then treatment is provided, but the mixtures do not interact optimally and are not stable enough for therapeutic use

Engineering Contradiction:

Improvestability of bacterial mixtureVSAvoidinteraction optimality

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies preliminary action by pre-adapting the bacterial consortium in a fermenter before administration to the subject. This pre-adaptation phase allows the bacterial species to establish stable interactions and functional relationships in advance, ensuring both stability and optimal interaction when the consortium is introduced to the gastrointestinal tract.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent combines multiple bacterial species into a single pre-adapted consortium that functions as an integrated therapeutic unit. By merging these species and allowing them to co-culture in the fermenter, the invention creates a synergistic mixture where the species interact optimally, resolving the contradiction between stability and interaction effectiveness.

Inventive Principle:

Principle #5Merging (Combining)

2Reliability

If single probiotic strains are introduced to treat dysbiosis, then probiotic therapy is provided, but survival during harsh digestive conditions is challenging and competition with indigenous microbiome is negligible

Engineering Contradiction:

Improvesurvival of probiotic strainVSAvoidcompetitive ability

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent merges multiple probiotic strains into a consortium that collectively provides enhanced survival capabilities and competitive ability. The diverse species within the consortium offer complementary functions, including different mechanisms for withstanding harsh digestive conditions and competing with indigenous microbiota, thereby resolving the limitations of single-strain probiotics.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite probiotic product consisting of multiple bacterial species that work together as an integrated system. This composite consortium combines the strengths of individual species, providing both improved survival under stress conditions and enhanced competitive ability against the indigenous microbiome through synergistic interactions established during pre-adaptation.

Inventive Principle:

Principle #40Composite materials

3Object-affected harmful factors

If broad-spectrum antibiotics are used to eliminate pathogens, then pathogen removal is achieved, but indigenous gut microorganisms are also targeted, worsening dysbiosis

Engineering Contradiction:

Improvepathogen eliminationVSAvoidpreservation of indigenous microbiome

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent converts the harm caused by antibiotic-induced dysbiosis into a benefit by introducing a pre-adapted bacterial consortium specifically designed to restore and stabilize the gut microbiome. This consortium targets pathogen elimination through competitive exclusion and produces antimicrobial substances, while simultaneously repopulating beneficial indigenous species, thereby transforming the harmful effect of antibiotic use into a restorative therapeutic outcome.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The pre-adapted bacterial mixture quickly and effectively modulates the gut microbiome, improving intestinal barrier function, immune response, and metabolic homeostasis, reducing inflammation and pathogen attachment, thereby treating or preventing a range of gastrointestinal and systemic health issues.

Implementation Method 1

the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentUS12458672B2Use of microbial communities for human and animal health

Publication Date: 2025.11.04 MICROBIAL RESOURCE MANAGEMENT HEALTH NV

AI summary

The disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria is grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.