Pre-cooling Reagents for Oligosaccharide Synthesis
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Solution Overview
Problem
Existing devices for automated synthesis of oligo- and polysaccharides on a solid support face challenges in achieving high yields and preventing side and decomposition products, particularly during scale-up and larger batch sizes, due to inadequate temperature control and reagent delivery.
Innovation Solution
A device comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for the reaction vessel, and a pre-cooling device that pre-cools reagents to a temperature close to the reaction mixture, preventing thermal spikes and decomposition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If automated synthesis is performed without pre-cooling reagents, then the synthesis process is simpler and faster to set up, but thermal spikes occur causing decomposition and side products
Solution Approach 1:
The patent applies preliminary action by pre-cooling reagents in a pre-cooling device before they are delivered to the reaction vessel. This advance preparation prevents thermal spikes when reagents are added to the reaction mixture, thereby preventing decomposition and side product formation without complicating the overall synthesis process.
Solution Approach 2:
The pre-cooling device acts as an intermediary component between the reagent storage and the reaction vessel. It mediates the temperature of reagents before they enter the reaction system, ensuring thermal compatibility and preventing harmful thermal effects while maintaining a relatively simple overall device architecture.
2Productivity
If larger batch sizes are used for synthesis, then productivity increases, but temperature control becomes inadequate leading to more decomposition
Solution Approach 1:
By pre-cooling reagents before addition, the system compensates for the reduced surface-area-to-volume ratio in larger batch sizes. This preliminary temperature adjustment ensures that even in larger reaction vessels where heat dissipation is less efficient, thermal spikes are prevented and temperature control remains adequate.
3Productivity
If reagents are added rapidly to increase throughput, then productivity improves, but thermal spikes cause decomposition
Solution Approach 1:
The pre-cooling device prepares reagents in advance by cooling them to the appropriate temperature before rapid delivery. This allows reagents to be added quickly to maintain high throughput while the pre-cooled state prevents thermal spikes and decomposition during the rapid addition process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enhances yield, reduces decomposition, and effectively prevents the formation of side products, especially in larger batch sizes, by maintaining stable temperatures and rapid reagent delivery, as demonstrated by improved analytical results and thermal profile control.
Implementation Method 1
a cooling device for cooling the reaction vessel
Implementation Method 2
a pre-cooling device for pre-cooling the reagents to be supplied
Data Source
AI summary
The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.