Predictive R Peak Timing for Intra-Aortic Balloon Pumps

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Solution Overview

Problem

Conventional systems for intra-aortic balloon pumps are sensitive to noise and inaccurately detect the timing of R waves in ECG signals, leading to inefficiencies in predicting the inflation and deflation of the balloon, which affects the timing of heart rhythm support.

Innovation Solution

A state machine-based facility that operates in initialization, learning, and peak detection states to predictively time R peaks by processing ECG signals using a power signal module and QRS detection module, employing adaptive thresholds and wavelet transforms to improve accuracy and reliability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional ECG signal processing methods are used, then the system is simpler to implement, but the detection precision of R wave timing is poor due to noise sensitivity

Engineering Contradiction:
ImproveR wave timing detection precisionVSAvoidsignal processing system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The ECG signal processing is divided into distinct stages: wavelet transform decomposition into approximation and detail coefficients, followed by separate processing of QRS complex detection and R peak timing prediction. This segmentation allows each stage to be optimized independently, improving overall detection precision while managing system complexity.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Wavelet transform coefficients serve as an intermediary representation between the raw ECG signal and the final R wave timing detection. By transforming the signal into the wavelet domain, noise is filtered out while preserving important cardiac features, thereby improving detection precision without requiring direct complex noise filtering on the raw signal.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If adaptive thresholding and wavelet transforms are implemented, then the reliability of R peak prediction improves, but the computational complexity increases

Engineering Contradiction:
ImproveR peak prediction reliabilityVSAvoidprocessing algorithm complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system performs preliminary wavelet transform and QRS complex detection before final R peak timing prediction. By preparing the signal in advance through decomposition and preliminary detection, the system establishes a reliable foundation for accurate R peak prediction, improving reliability while organizing complexity into manageable preprocessing steps.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system uses adaptive thresholding that adjusts based on the detected signal characteristics and previously detected R peaks. This feedback mechanism allows the detection algorithm to self-correct and adapt to varying signal conditions, improving reliability without requiring manual calibration or overly complex fixed-threshold systems.

Inventive Principle:
Principle #23Feedback

3Productivity

If predictive timing of R peaks is used, then the balloon pump operation efficiency improves, but the requirement for signal processing accuracy increases

Engineering Contradiction:
Improveballoon pump operation efficiencyVSAvoidECG signal processing accuracy
Core Design Contradiction:
ProductivityVSMeasurement precision

Solution Approach 1:

The system dynamically adjusts detection parameters and thresholds based on the detected ECG signal characteristics and heart rate variability. This dynamic adaptation allows the system to maintain high prediction accuracy for R peaks under varying physiological conditions, ensuring efficient balloon pump operation without requiring static high-precision thresholds.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The system performs preliminary QRS complex detection and R peak identification before using these results to guide balloon pump timing. By establishing accurate reference points in advance through careful signal processing, the system enables efficient predictive timing operations without requiring continuous high-precision processing at full speed.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS12178586B2Predictive QRS detection and R-to-R timing systems and methods
Publication Date: 2024.12.31 NUPULSECV INC
  • US12178586B2 patent drawing
  • US12178586B2 patent drawing
  • US12178586B2 patent drawing

AI summary

The present disclosure is directed towards systems and methods built for predictively timing the inflation and/or deflation of an intra-aortic balloon pump. A controller operates in three states: (1) initialization state, (2) learning state, and (3) peak detection state. The controller decomposes a patient's electrocardiogram signal to a power signal. It then learns characteristics of the patient's electrocardiogram signal during the learning state and computes adaptive threshold parameter values. During the peak detection state, the controller applies the learnt threshold parameter values on a current electrocardiogram signal to identify occurrence and timings of R peaks in the electrocardiogram signal. The R-to-R peak timings are then used to trigger inflation of an intra-aortic balloon pump.