Predonation Blood Bag with EDTA for Centralized Sample Filling

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Solution Overview

Problem

Existing blood collection systems require on-site sampling and filling of sample containers with anticoagulant, which can interfere with analysis and compromise sterility, and lack automation for centralized processing.

Innovation Solution

A predonation bag system with a dedicated anticoagulant, such as EDTA, diverts whole blood into a predonation bag during collection, allowing centralized and automated filling of sample containers in a laboratory, preventing contamination and interference with analysis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If sample containers are filled on-site at the blood collection site, then the blood collection process can be completed quickly, but the sterility of the system is compromised and contamination by airborne bacteria occurs

Engineering Contradiction:

Improveblood collection speedVSAvoidsterility contamination

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The blood collection system is segmented into two separate bags: a first blood bag for collecting whole blood and a second blood bag for receiving separated blood components. This segmentation allows the sample containers to be filled in the laboratory after separation, maintaining sterility while completing the collection process efficiently.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The system performs preliminary separation of blood components in the first blood bag before transferring to the second blood bag. This preliminary action enables centralized sample container filling in the laboratory without compromising sterility, as the separation is completed before the final transfer.

Inventive Principle:

Principle #10Preliminary action

2Device complexity

If the same anticoagulant is used in the whole blood bag and sample containers, then the system is simplified, but the anticoagulant interferes with blood analysis

Engineering Contradiction:

Improvesystem simplicityVSAvoidblood analysis accuracy

Core Design Contradiction:

Device complexityVSMeasurement precision

Solution Approach 1:

Different anticoagulants are used in different parts of the system: citrate-based anticoagulant in the first blood bag for whole blood collection, and EDTA-based anticoagulant in the sample containers for analysis. This local differentiation ensures that each component receives the appropriate anticoagulant without interference with subsequent analysis.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The first blood bag acts as an intermediary between blood collection and sample container filling. It receives whole blood, performs separation, and transfers components to the second blood bag, allowing different anticoagulants to be used in different stages without direct conflict.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Productivity

If blood separation and component transfer are performed on-site, then the collection process is completed quickly, but centralized laboratory processing and automation are lost

Engineering Contradiction:

Improvecollection completion speedVSAvoidcentralized processing capability

Core Design Contradiction:

ProductivityVSExtent of automation

Solution Approach 1:

The system segments the blood collection and processing into distinct stages: on-site whole blood collection in the first blood bag, followed by centralized separation and component transfer to the second blood bag in the laboratory. This segmentation enables automation of the laboratory processing steps while maintaining quick on-site collection.

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables centralized, automated, and contamination-free filling of sample containers, improving the efficiency and accuracy of blood analysis by using a different anticoagulant in the predonation bag that does not interfere with laboratory tests.

Implementation Method 1

the predonation bag or the first tubing section or both comprises/comprise an anticoagulant for whole blood and the anticoagulant is EDTA

Methodology Applied

Scientific EffectChelation:

Implementation Method 2

The separation is carried out by centrifugation. During centrifugation, an upper plasma layer, possibly a thinner intermediate layer known as the 'buffy coat layer', which contains the leukocytes and thrombocytes, and a lower layer of erythrocytes (red blood cells) are obtained.

Methodology Applied

Scientific EffectCentrifugal separation: Centrifugal Separation

Data Source

PatentUS20260007809A1Predonation bag system containing an anticoagulant, and blood bag system comprising the predonation bag system

Publication Date: 2026.01.08 BLUTSPENDEDIENST LANDESVERBANDE DES DRK NIEDERSACHSEN SACHSEN ANHALT THURINGEN OLDENB BREMEN GGMBH

AI summary

The invention relates to a predonation bag system comprising a predonation bag to be filled with whole blood during the blood removal. an anticoagulant being added to the whole blood in the predonation bag and sample containers being automatedly filled with the whole blood from the predonation bag only in the laboratory for blood analysis. The predonation bag system is part of a blood bag system. The invention also relates to corresponding method for removing blood by means of the predonation bag system and for analyzing the whole blood of each donor.