Prefilled Bioprocess Liquid Container for Sterile Precise Dosing
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Solution Overview
Problem
The challenge in bioprocessing systems, particularly for producing ATMPs, is the precise and sterile addition of liquid media into bioreactors, which is costly and prone to contamination due to the need for cleanroom handling and multiple sterile connections.
Innovation Solution
A small-volume liquid container with a shape-changeable delimitation means that allows for precise filling and dispensing of a liquid medium without requiring on-site filling or sterile connectors, ensuring sterility and ease of use by being prefilled and prepackaged.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liquid medium is transferred using syringes or vials in cleanrooms, then sterility is maintained, but operation complexity and costs increase due to multiple sterile connectors and filters
Solution Approach 1:
The patent combines the liquid container, dispensing mechanism, and connection interface into a single integrated unit. The container includes an accommodation volume for the liquid medium, a piston for dispensing, and a connection element with integrated valve, eliminating the need for separate sterile connectors and filters that complicate the operation.
Solution Approach 2:
The connection element serves multiple functions: it provides sterile sealing, controls liquid flow through an integrated valve, and enables direct connection to the bioprocessing system. This multi-functional design replaces multiple separate components (connectors, filters, valves) that would otherwise be needed to maintain sterility.
2Adaptability or versatility
If manual filling and handling of liquid containers is performed, then flexibility is maintained, but contamination risk increases and productivity decreases
Solution Approach 1:
The liquid container is pre-filled with the exact required quantity of liquid medium under sterile conditions before use. This preliminary action eliminates the need for on-site filling operations, thereby increasing productivity while maintaining sterility through the pre-sterilized sealed container.
Solution Approach 2:
The liquid container is designed as a single-use disposable unit that is pre-filled and sealed. After use, the entire container is discarded, eliminating the need for complex cleaning and sterilization procedures and enabling rapid replacement, thereby increasing productivity while maintaining high sterility standards.
3Manufacturing precision
If precise dosing is achieved through manual measurement, then dosing accuracy is improved, but time consumption and contamination risk increase
Solution Approach 1:
The liquid container is pre-filled with the exact required quantity of liquid medium during manufacturing under sterile conditions. This preliminary dosing action ensures precise dosing accuracy while eliminating the time-consuming and contamination-prone manual measurement and transfer operations that would otherwise be required.
Data Source
AI summary
A small-volume liquid container for dispensing a liquid medium, especially biological medium, into a bioprocessing system, especially into a bioreactor, wherein the liquid container provides an accommodation volume for the liquid medium, wherein the liquid container comprises two dimensionally stable container parts, which are movable relative to one another between an initial position and an end position, and an outlet connection for discharge of the liquid medium. It is proposed that the liquid container comprises a shape-changeable delimitation means which at least sectionally delimits the accommodation volume and which is connected to the dimensionally stable container parts in such a way that a relative movement of the dimensionally stable container parts to one another, causing a change in volume of the accommodation volume, is associated with a change in shape of the delimitation means.