Prefilled Thixotropic Containers for Standardized Wound Healing Gels

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Conventional wound healing membranes and patches are complex, costly, non-standardized, and lack consistency, safety, and efficiency, often produced in unsanitary conditions, leading to a low benefit-to-risk ratio.

Innovation Solution

The development of containers and methods for producing standardized, reproducible, and safe preparations of Platelet Rich Plasma (PRP) or Bone Marrow Concentrate (BMC) using prefilled centrifugation tubes or syringes with thixotropic gel, coagulation activators, and anticoagulants, enabling efficient and sterile production of topical gels or patches.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If conventional membranes and patches are produced using traditional methods, then production flexibility is maintained, but manufacturing complexity increases and consistency deteriorates

Engineering Contradiction:

Improvestandardization and consistencyVSAvoidproduction process complexity

Core Design Contradiction:

Manufacturing precisionVSDevice complexity

Solution Approach 1:

The production process is segmented into distinct functional components: pre-filled containers with specific formulations, centrifugation steps, and controlled mixing sequences. This segmentation enables standardization of each step while reducing overall process complexity through modular execution.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Containers are pre-filled with specific formulations (thixotropic gels, coagulation activators, anticoagulants) before use. This preliminary action ensures consistent starting conditions for each production run, improving manufacturing precision while simplifying the operational process.

Inventive Principle:

Principle #10Preliminary action

2Reliability

If conventional membranes and patches are produced in open environments, then production cost is reduced, but contamination risk increases

Engineering Contradiction:

Improvesafety and contamination controlVSAvoidproduction simplicity

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The system uses pre-filled sealed containers that maintain a controlled environment throughout the preparation process. This creates an inert protective atmosphere that prevents contamination while keeping the manufacturing process simple and cost-effective.

Inventive Principle:

Principle #39Inert atmosphere (Inert environment)

Solution Approach 2:

The pre-filled containers are designed to self-protect against contamination through their sealed design. The system serves its own safety needs through inherent container design rather than requiring complex external contamination control measures.

Inventive Principle:

Principle #25Self-service

3Productivity

If conventional membranes and patches are produced manually, then operational flexibility is maintained, but production time increases

Engineering Contradiction:

Improvepreparation speedVSAvoidproduction time

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

Containers are pre-filled with all necessary components before use. This preliminary preparation eliminates time-consuming setup steps during actual production, significantly improving preparation speed while maintaining operational simplicity.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Multiple components (thixotropic gel, coagulation activator, anticoagulant) are merged into a single pre-filled container. This consolidation reduces the number of separate preparation steps and materials handling operations, decreasing overall production time.

Inventive Principle:

Principle #5Merging (Combining)

4Manufacturing precision

If conventional membranes and patches are produced without standardized formulations, then formulation flexibility is maintained, but product quality consistency deteriorates

Engineering Contradiction:

Improveformulation consistencyVSAvoidformulation flexibility

Core Design Contradiction:

Manufacturing precisionVSAdaptability or versatility

Solution Approach 1:

The formulation is segmented into distinct functional components (thixotropic gel, coagulation activator, anticoagulant) each with standardized specifications. This segmentation enables consistent quality control of each component while allowing flexibility in selecting specific product combinations for different applications.

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides efficient, safe, and standardized wound healing products with improved adherence and stability, reducing preparation time and minimizing contamination risks, while maintaining high platelet counts and pH levels.

Implementation Method 1

The container is filled with blood or bone marrow and then centrifuged to separate red blood cells from platelet-rich plasma

Methodology Applied

Scientific EffectCentrifugal separation: Centrifugal Separation

Implementation Method 2

The container comprises or is prefilled with or comprises at least one thixotropic gel and a composition comprising at least one coagulation activator

Methodology Applied

Scientific EffectCoagulation: Coagulation

Data Source

PatentUS20250275914A1Preparation method and container for a topical wound healing gel

Publication Date: 2025.09.04 REGENLAB USA LLC

AI summary

The present invention relates to a container for use in the preparation of a topical gel or topical membrane or topical patch formed from a PRP or BMC-coagulation activator combination, in which the container is prefilled with or comprises at least one thixotropic gel and a composition comprising at least one coagulation activator.