Preload Meal Composition for Incretin Stimulation and Weight Management
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Solution Overview
Problem
Current approaches to managing obesity and type 2 diabetes often result in poor nutritional intake or nutritional deficiencies, and popular low-calorie diets fail to provide sustainable weight loss, while novel drugs for obesity lack a definitive cure.
Innovation Solution
The 'Preload' method involves administering a 50-110 kcal food composition product 25-35 minutes before meals, comprising proteins from yellow pea, whey, and omega 3-rich eggs, along with slowly digested carbohydrates and dietary fibers, to stimulate incretin release, increase satiety, and lower postprandial blood sugar levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Weight of moving object
If a low-calorie diet is administered to treat obesity and diabetes, then weight loss is achieved, but nutritional deficiencies occur and weight loss is not sustainable
Solution Approach 1:
The invention administers a preload meal 25-35 minutes before the main meal to prime the incretin system. This preliminary action of stimulating incretin release before meal consumption enhances satiety signals and insulin response, allowing for reduced overall calorie intake while maintaining nutritional adequacy and sustainability
Solution Approach 2:
The invention changes the temporal parameter of meal consumption by introducing a pre-meal intervention at a specific time window (25-35 minutes before eating). This temporal parameter change optimizes the physiological response to food intake, improving weight loss sustainability without compromising nutrition
2Object-affected harmful factors
If a preload meal is administered to stimulate incretin release and reduce postprandial blood sugar, then blood glucose control is improved, but additional caloric intake is added before meals
Solution Approach 1:
The preload meal provides a small, controlled amount of calories (50-110 kcal) that is intentionally less than a full meal. This partial action is sufficient to trigger the desired incretin response and improve blood glucose control without providing excessive calories that would undermine weight loss goals
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Preload Meal significantly reduces body weight, BMI, and fat percentage, improves blood lipids, insulin levels, and quality of life parameters, while maintaining stable blood glucose and insulin levels over a prolonged period.
Implementation Method 1
wherein said food composition product includes nutrients such that release of incretins in said subject is stimulated prior to said main meal
Data Source
Figure 1a~1b
AI summary
Method for orally administrating a subject a food composition product including 50 to 10 kcal "Preload meal" before administrating a main meal, i.e. breakfast, lunch or dinner, to said subject and said food composition product to include nutrients, such that release of incretins in said subject is stimulated prior to said main meal, said food composition product comprising of at least two different proteins deriving from both animal and vegetable sources, furthermore Omega 3 and 6 fatty acids and slowly digested carbohydrates including dietary fibers, giving said composition a low glycemic load (GL <10), thereby increasing satiety of subject and lowering total energy intake including both food composition product and main meal; the method comprising administration of said food composition product contributing to a biological control of the post prandial blood sugar and insulin levels.