Pressure-Controlled Injection Port for Targeted Vascular Delivery
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Solution Overview
Problem
Current medical treatments for conditions like pancreatic cancer and diabetes face challenges in delivering therapeutic agents effectively to target tissues due to inadequate concentration and unintended distribution, often resulting in reduced efficacy and health risks.
Innovation Solution
A system incorporating a pressure-detecting element and infusion timing element allows for targeted infusion of therapeutic agents into specific vessels based on localized pressure changes or timing events, using a dynamic or static occlusion device to ensure higher pressure delivery directly to the target area, minimizing reflux and maximizing tissue uptake.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If systemic treatments are administered, then the treatment can reach target tissue, but the treatment concentration is insufficient and distribution is unintended
Solution Approach 1:
The invention segments the vascular system into target and non-target regions using an occlusion device that isolates the target tissue's blood supply. This allows concentrated delivery of therapeutic agents specifically to the target tissue while preventing systemic distribution, thereby increasing treatment concentration at the target site while maintaining reliable targeted delivery.
Solution Approach 2:
The invention creates local quality by establishing a localized high-concentration environment within the target tissue's vascular bed. The occlusion device prevents treatment agent from distributing systemically, ensuring that the highest concentration is maintained locally at the target site, which directly addresses both the need for high treatment concentration and accurate targeted delivery.
2Quantity of substance
If intra-arterial chemotherapy is delivered through small catheters, then higher drug concentration can reach the tumor, but catheter localization is difficult due to redundant blood supply and small branch size
Solution Approach 1:
The invention applies preliminary action by performing vascular mapping and identifying the target feeder vessel before catheter insertion. The occlusion device is then positioned in advance to isolate the target vascular bed, making subsequent catheter localization and drug delivery straightforward. This preliminary preparation eliminates the difficulty of locating small branches during the actual treatment delivery.
3Quantity of substance
If treatment is infused under significant pressure, then the treatment can overcome blood pressure and reach target tissue, but the treatment can reflux into healthy tissues causing harm
Solution Approach 1:
The invention extracts or removes the harmful reflux pathway by using an occlusion device to block the vascular path leading to healthy tissues. This allows high-pressure infusion to effectively deliver treatment to the target tissue without the treatment refluxing into healthy tissues, as the occlusion device creates a one-way flow path that prevents backward flow.
4Quantity of substance
If occlusion devices are used to isolate target vascular bed, then treatment can be concentrated at target site, but the system complexity increases
Solution Approach 1:
The occlusion device is designed with multi-functionality, serving both as a vascular isolator to concentrate treatment at the target site and as a platform for subsequent catheter placement and drug delivery. This universal design reduces overall system complexity by combining multiple functions into a single device rather than requiring separate components for each function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the concentration of therapeutic agents in target tissues, reduces systemic side effects, and improves treatment efficacy by ensuring precise delivery and penetration, even to previously inaccessible areas.
Implementation Method 1
a pressure-detecting element and an infusion timing element adapted to permit injection of the infusate based on a localized pressure or timing event
Implementation Method 2
When the treatment agent is infused, the pressure in the vessel downstream (distal) of the treatment is always higher than that upstream (proximal) of the treatment, causing the microvalve to open and block reflux of the agent
Data Source
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AI summary
A treatment system includes a guide sheath, and a catheter provided with a pressure-controlled element. The pressure-control element preferably includes an expanded configuration adapted to extend across a small feeder vessel branching from the splenic vein. The pressure-control element is positioned with the feeder vessel, and a therapeutic agent is delivered under pressure directly into the feeder vessel, where it is forced to penetrate deep into tissue. Pressure responsive elements for monitoring intravascular pressure are also provided to time delivery of the therapeutic agent for maximum uptake by the target organ. Methods for treating tissues and organs via vascular pathways are provided.