Pressure Guidewire Assessment Using Multi-Beat dPRc Ratios
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for determining vascular occlusion treatment, such as fractional flow reserve (FFR), are limited by relying on diastolic pressure measurements alone, which do not provide comprehensive data for accurate clinical decision-making.
Innovation Solution
A system and method that calculates a metric (dPRc) using both aortic and distal pressure curves, incorporating data from multiple heartbeat cycles and segments, to assess vascular conditions more accurately.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If only diastolic pressure measurements are used, then the measurement process is simple and quick, but the assessment accuracy and comprehensiveness are limited
Solution Approach 1:
The patent segments the heartbeat cycle into multiple phases (systole, diastole, dicrotic notch) and calculates pressure ratios for each segment. This allows comprehensive assessment of vascular function throughout the entire cardiac cycle rather than relying on a single diastolic measurement, thereby improving assessment accuracy while maintaining computational feasibility through systematic breakdown of the measurement process.
2Loss of information
If data from multiple heartbeat cycles and segments are incorporated, then the comprehensiveness of cardiovascular assessment is improved, but the complexity of data processing increases
Solution Approach 1:
The patent merges pressure data from multiple heartbeat cycles and segments into a unified multi-beat metric (dPRc). By combining information from systolic, diastolic, and dicrotic notch phases across multiple beats, the system achieves comprehensive cardiovascular assessment. The merging process integrates these diverse data sources into a single comprehensive metric that captures the full complexity of vascular function.
Solution Approach 2:
The patent transitions from single-beat, single-phase pressure ratio measurements to multi-beat, multi-phase analysis by adding temporal dimensions. The system analyzes pressure data across multiple heartbeat cycles and multiple phases within each cycle, effectively moving from a one-dimensional measurement approach to a multi-dimensional assessment that captures cardiovascular function more completely.
3Measurement precision
If traditional FFR with hyperemia is used, then the gold standard assessment is achieved, but the invasiveness and complexity of the procedure increase
Solution Approach 1:
The patent extracts the essential assessment information from the complex hyperemic FFR procedure by analyzing pressure ratios during normal resting heartbeat cycles. Instead of requiring pharmacologically induced hyperemia, the system extracts meaningful vascular function data from routine pressure measurements taken during standard cardiac cycles, thereby simplifying the procedure while maintaining diagnostic value.
Solution Approach 2:
The system utilizes the heart's own natural pressure variations during regular heartbeat cycles to assess vascular function. By analyzing the inherent pressure fluctuations that occur during normal systole, diastole, and dicrotic notch phases, the system enables the cardiovascular system to provide its own assessment data without requiring external pharmacological intervention or hyperemic stimulation.
Data Source
AI summary
A system for assessing a vascular condition includes a pressure sensing catheter and a pressure guidewire. Heartbeats of the patient can be detected while the pressure sensing catheter and the pressure guidewire are positioned at the proximal position and at a distal position respectively. A diastolic pressure ratio zone (dPR zone) is located within a heartbeat from analysis of a signal from at least one of the pressure sensing catheter and the pressure guidewire. The dPR value can be obtained by calculating an average of several ratios of Pa to Pd taken over time within the heartbeat. A multi-beat metric (dPRc) is calculated that includes the dPR value and that also includes a high frequency sample whole heartbeat pressure ratio.