Pressurized Aerosol Spray Device for Targeted Chemotherapy Delivery
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Solution Overview
Problem
Current methods for delivering chemotherapy to body cavities, such as HIPEC, often expose the entire body to toxic chemicals and lack efficient distribution of therapeutic agents within the cavity.
Innovation Solution
A spray device with axial and radial spray holes is used to deliver aerosolized chemotherapeutic agents directly into body cavities, allowing for targeted treatment while minimizing systemic toxicity through a combination of axial and radial spray configurations and pressurized delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If HIPEC is used to deliver chemotherapeutic agent within the abdominal cavity, then the efficacy of treatment is improved, but the normal side-effects of chemotherapy cannot be completely avoided
Solution Approach 1:
The delivery system is segmented into multiple components: a catheter for fluid delivery, a separate aerosol generation device, and a distribution system with multiple spray nozzles. This segmentation allows the chemotherapeutic agent to be delivered through different pathways (both liquid and aerosol forms) to different areas of the body cavity, improving distribution while maintaining localized delivery to reduce systemic toxicity
Solution Approach 2:
The patent changes the physical state parameter of the chemotherapeutic agent from purely liquid to a combination of liquid and aerosol phases. The aerosolization process transforms the delivery form, enabling better penetration and distribution throughout the body cavity while maintaining high local concentration at the treatment site, thus improving efficacy without proportionally increasing systemic exposure
2Productivity
If a spray device with axial and radial spray holes is used to deliver aerosolized substance, then the distribution of therapeutic agent is enhanced, but the device complexity increases
Solution Approach 1:
The spray device is divided into distinct functional segments: axial spray holes for forward-directed delivery along the catheter axis, and radial spray holes for outward-directed delivery perpendicular to the axis. This segmentation of spray directions allows comprehensive coverage of the body cavity while keeping each individual spray component relatively simple in design
Solution Approach 2:
The spray device is designed with multi-functionality by incorporating both axial and radial spray capabilities in a single device structure. This universal design allows the device to perform multiple delivery functions (directional spraying, omnidirectional spraying) without requiring multiple separate devices, thus improving distribution efficiency while limiting the increase in overall complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables high-dose, localized chemotherapy within body cavities with enhanced distribution and reduced systemic side effects, improving treatment efficacy for cancers in body cavities.
Implementation Method 1
The elongate member is configured to receive a substance at the proximal portion and deliver the substance from the distal portion in an aerosolized form
Implementation Method 2
The axial and radial spray holes are configured to cause the substance to exit from the distal portion in an aerosolized form
Data Source
AI summary
A spray device, method, and system for delivering an aerosolized therapeutic agent to a body cavity of a patient, for example, in conjunction with administration of chemotherapeutic agents. A longitudinal spray device/nebulizer that directs an aerosolized substance in both an axial direction and a radial direction.