Pressurized Membrane Reservoir for Fast Drug Diffusion

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Solution Overview

Problem

Current drug delivery devices rely on natural diffusion, which is slow, affecting medication release and efficacy, and lack efficient mechanisms for controlled release of substances from sealed cavities.

Innovation Solution

A digital biomedical device with a pressurized membrane comprising a first and second layer with strain, configured to curl and open a reservoir, accelerating diffusion by creating a substantial opening, utilizing stress engineering and controlled activation to enhance medication release.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If natural diffusion is used for medication release, then the device structure is simple, but the diffusion speed is slow affecting medication efficacy

Engineering Contradiction:
Improvediffusion speedVSAvoiddevice structure
Core Design Contradiction:
SpeedVSDevice complexity

Solution Approach 1:

The membrane is pre-strained during manufacturing to store elastic energy, creating a pressurized state that will automatically curl and open the reservoir upon activation. This preliminary preparation enables fast diffusion without requiring complex active pumping mechanisms during operation

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The strained membrane serves dual functions: it acts as both the sealing mechanism and the driving force for opening the reservoir. When activated, the stored strain energy automatically curls the membrane to open the reservoir, eliminating the need for separate actuators or complex control mechanisms

Inventive Principle:
Principle #25Self-service

2Productivity

If a pressurized membrane is used to accelerate diffusion, then the medication release speed improves, but the device complexity increases

Engineering Contradiction:
Improvemedication release rateVSAvoidmembrane structure
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The membrane's physical state is changed by introducing strain during manufacturing, transforming it from a passive seal to an active, pressurized component. This parameter change enables the membrane to automatically curl and open the reservoir, significantly accelerating medication release without adding complex mechanical structures

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The membrane utilizes a composite structure with multiple layers having different mechanical properties, allowing one layer to be strained while maintaining the overall structural integrity of the seal. This composite approach enables the pressurized functionality while maintaining manufacturing feasibility

Inventive Principle:
Principle #40Composite materials

3Reliability

If the membrane is sealed tightly to maintain pressure, then the controlled release capability improves, but the activation mechanism becomes more complex

Engineering Contradiction:
Improvecontrolled release capabilityVSAvoidactivation mechanism
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The strained membrane automatically responds to activation by curling and opening the reservoir through its stored elastic energy. This self-service mechanism eliminates the need for complex external actuators, motors, or multi-component activation systems while maintaining reliable controlled release capability

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution achieves fast and controlled diffusion of medication or fluid into and out of cavities, with the membrane opening significantly, improving medication delivery and efficacy by over 50% of the cavity width.

Implementation Method 1

a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir

Methodology Applied
Scientific EffectStrain: Deformation

Implementation Method 2

the pressure difference will help accelerate the diffusion into and out of the cavities

Methodology Applied
Scientific EffectDiffusion: Diffusion

Data Source

PatentUS10940265B2Drug delivery device having a cavity sealed by a pressurized membrane
Publication Date: 2021.03.09 INTERNATIONAL BUSINESS MACHINE CORPORATION
  • US10940265B2 patent drawing
  • US10940265B2 patent drawing
  • US10940265B2 patent drawing

AI summary

A digital biomedical device includes a substrate forming a reservoir, a membrane comprising a first layer and a second layer having a strain therebetween, the membrane sealing the reservoir, and a controller configured to activate the membrane and release at least a portion of the strain causing the membrane curl and open the reservoir.