Pressurized Nitric Oxide Delivery System for Wound Healing
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Solution Overview
Problem
Current methods for delivering nitric oxide (NO) for wound healing are limited by toxic side effects of carrier compounds, inconsistent release of NO, and the need for direct exposure to a gas cylinder, making them impractical for short-term applications or use on skin and mucosal membranes.
Innovation Solution
A gas-evolving composition delivery system using a pressurized container with a dispenser, containing a gas-evolving donor, an activator, and a pharmaceutically acceptable carrier, which minimizes gas production until administration and allows controlled release of NO, stabilizing an acidified nitrite solution to maintain therapeutic concentrations over extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If direct exposure to nitric oxide gas is used for treatment, then therapeutic effects on biological systems are achieved, but the patient requires continuous connection to a gas cylinder for hours, making it impractical for short-term applications
Solution Approach 1:
The patent changes the physical state of nitric oxide from gas to a stable liquid or solid formulation that can be stored and transported without continuous gas cylinder connection. The composition maintains nitric oxide in a controlled state that releases the gas therapeutically when needed, eliminating the need for hours-long connection to gas cylinders while preserving therapeutic effects
Solution Approach 2:
The patent prepares nitric oxide in advance in a stable formulation (liquid or solid composition) that can be stored and transported. This preliminary preparation allows the therapeutic agent to be ready for use without requiring continuous gas cylinder connection during treatment, enabling short-term applications and improving ease of operation
2Ease of operation
If solid, liquid, or cream NO donors are used, then portability is improved, but toxic side effects occur due to carrier compounds and acidic environment for release
Solution Approach 1:
The patent modifies the chemical parameters of the nitric oxide formulation by using a non-acidic release mechanism. Instead of relying on acidic environments that cause tissue irritation and toxicity, the composition releases nitric oxide through a controlled process that maintains physiological pH, eliminating toxic side effects while preserving portability
Solution Approach 2:
The patent introduces a safe carrier system that acts as an intermediary between the nitric oxide source and biological tissues. This carrier compound-free or minimally-invasive formulation system delivers nitric oxide without the toxic side effects associated with traditional carrier compounds, allowing portable delivery methods to be used safely
3Reliability
If endogenous approaches such as intracellular NOS stimulation or exogenous wound dressings with NO-donors are used, then wound healing is targeted, but consistent steady-state concentrations of NO are not released
Solution Approach 1:
The patent creates a formulation that provides continuous and consistent release of nitric oxide at steady-state concentrations. The composition is designed to maintain a stable release rate over time, ensuring continuous therapeutic action at the wound site without the inconsistent concentration profiles that plague traditional NO-donor dressings and endogenous approaches
4Stability of the object's composition
If nitric oxide is bound with other compounds in preparations, then formulation stability is improved, but adequate efficacy is not demonstrated
Solution Approach 1:
The patent extracts nitric oxide from bound or complexed states and delivers it in a free or minimally-complexed form that maintains both formulation stability and therapeutic efficacy. The composition allows nitric oxide to remain sufficiently unbound to interact with biological targets effectively while the formulation structure provides overall stability during storage and delivery
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables stable and controlled release of NO for therapeutic effects, such as antimicrobial action and wound healing, without the need for continuous gas exposure, facilitating ambulatory treatment and improved efficacy in wound care.
Implementation Method 1
The internal pressure of the pressurized container can be sufficient to minimize gas production of the gas-evolving composition while within the container
Implementation Method 2
The gas-evolving composition can comprise: a gas-evolving donor, an activator, and a pharmaceutically acceptable carrier
Data Source
AI summary
A gas-evolving composition delivery system is disclosed, which comprises a pressurized container having a dispenser, and a liquid gas-evolving composition, such as an acidified nitrite solution, within the pressurized container, wherein the pressurized container has an internal pressure sufficient to minimize gas production from the gas-evolving composition while within the container. Also disclosed is a method of stabilizing an acidified nitrite solution comprising loading the solution into a container and sealing the container to be airtight.