Pretreatment Apparatus Temperature Control Centrifugation
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Solution Overview
Problem
Existing pretreatment apparatuses for cell analysis, such as those described in Japanese Patent Applications 2015-508177 and 03-17536, often fail to maintain appropriate temperatures for each step of the pretreatment process, leading to suboptimal sample preparation for analysis.
Innovation Solution
A cell pretreatment apparatus with a temperature adjustment device that allows users to set and control the temperature for each step of the pretreatment process, including centrifugation, reagent dispensing, and reaction temperatures, using a controller and display interface to manage temperature settings and operations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If fixed temperature tanks are used for each pretreatment step, then temperature control is provided for specific steps, but the system becomes complex and cannot accommodate flexible temperature requirements for different analysis items
Solution Approach 1:
The single temperature control tank is designed to perform multiple functions by sequentially accommodating different containers for different pretreatment steps. The tank can hold various containers (reaction containers, centrifugal separation containers, etc.) and adjust temperature according to different analysis items, replacing the need for multiple fixed-temperature tanks.
Solution Approach 2:
The temperature control system is made dynamic by allowing the tank to adjust its temperature based on different analysis items and pretreatment steps. The controller modifies the tank temperature according to user input and predefined programs, enabling flexible temperature changes rather than using fixed-temperature tanks.
2Reliability
If multiple fixed temperature tanks are provided, then each step can be performed at appropriate temperature, but the device complexity and space requirements increase
Solution Approach 1:
The pretreatment process is segmented into multiple steps that can be performed sequentially in the same temperature control tank. Different containers are used for different steps (reaction, centrifugal separation, etc.), but they all share the same temperature control environment, reducing the need for multiple physical tanks.
Solution Approach 2:
The temperature control tank acts as an intermediary environment that supports multiple pretreatment operations. By controlling the tank temperature and sequentially placing different containers within it, the system provides appropriate temperature conditions for each step without requiring separate dedicated tanks for each operation.
3Ease of manufacture
If temperature is not controlled during pretreatment, then the apparatus is simpler, but the sample preparation quality deteriorates
Solution Approach 1:
The system controls temperature as a critical parameter throughout the pretreatment process. The temperature control tank maintains specific temperature ranges required for different pretreatment steps (reaction, centrifugal separation, etc.), ensuring sample preparation quality while keeping the apparatus design relatively simple compared to multiple fixed-temperature tanks.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures that each pretreatment step is performed at the desired temperature, enhancing the quality of the sample preparation for analysis by allowing precise temperature control throughout the process.
Implementation Method 1
a centrifugal separation device (600) for rotating the container (10) in the holder (610) to perform a centrifugal separation
Implementation Method 2
a temperature adjustment device (420) for adjusting the temperature of the sample in the container (10) in the holder (610)
Data Source
AI summary
A pretreatment apparatus (100) for performing pretreatment of a sample is provided with a holder (610) for holding a container (10) containing a sample, a centrifugal separation device (600) for rotating the container (10) held by the holder (610) to perform a centrifugal separation, a temperature adjustment device (420) for adjusting the temperature of the sample in the container (10) in the holder (610), an input device (320) for receiving from a user a designated temperature that is adjusted by the temperature adjustment device (420), a controller (300) for controlling the temperature adjustment device (420) in accordance with the designated temperature received via the input device (320).