Proanthocyanidin and Centella asiatica combination for atherosclerosis plaque stabilization
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Solution Overview
Problem
Current treatments and prevention methods for atherosclerosis, particularly affecting arteries, are inadequate in effectively addressing the formation and progression of atherosclerotic plaques, which can lead to severe cardiovascular events such as heart attacks and strokes.
Innovation Solution
A combination of proanthocyanidins, preferably procyanidins, and Centella asiatica extracts, administered in a suitable excipient, is used to prevent or treat atherosclerosis, offering a synergistic effect that stabilizes atherosclerotic plaques and reduces the risk of cardiovascular events.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments and prevention methods are used for atherosclerosis, then some level of plaque management is achieved, but they are inadequate in effectively addressing the formation and progression of atherosclerotic plaques
Solution Approach 1:
The patent combines proanthocyanidins and Centella asiatica extracts into a single pharmaceutical composition to achieve synergistic effects. This merging of two distinct therapeutic agents addresses the inadequacy of conventional single-agent treatments, providing enhanced plaque stabilization and inhibition of atherosclerosis progression that neither agent achieves alone.
Solution Approach 2:
The invention creates a composite pharmaceutical formulation integrating proanthocyanidins and Centella asiatica extracts. This composite approach leverages the complementary mechanisms of action between the two components - proanthocyanidins for antioxidant and anti-inflammatory effects, and Centella asiatica for fibrosis inhibition and plaque stabilization - to overcome the limitations of conventional monotherapies.
2Reliability
If proanthocyanidins and Centella asiatica are combined, then plaque stability is improved and cardiovascular risks are reduced, but the treatment complexity increases
Solution Approach 1:
The patent merges proanthocyanidins and Centella asiatica extracts into a single integrated pharmaceutical composition, simplifying the treatment regimen despite the complexity of combining multiple active ingredients. This unified formulation delivers synergistic therapeutic effects for plaque stabilization while maintaining ease of administration as a single agent.
Data Source
AI summary
The invention relates to a preparation for medical purposes and more specifically to a preparation consisting of the combination of proanthocyanidins such as Pycnogenol or grape seeds and Centella asiatica and/or extracts thereof, for use in the prevention or treatment of atherosclerosis.