Probe Irradiation Control for Consistent AGEs Fluorescence Detection

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Solution Overview

Problem

Existing measurement devices for detecting advanced glycation end products (AGEs) face variability in measurement values due to misalignment of excitation light irradiation locations, leading to unreliable results.

Innovation Solution

A measurement device and method that includes an excitation light irradiation section and a light receiving section, where a specific location on the body is calculated and consistently irradiated to reduce variation in fluorescence measurement, using a probe and control device to adjust the irradiation location and angle for precise fluorescence intensity measurement.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a measurement device irradiates a living body with excitation light to detect fluorescence for AGEs measurement, then the ability to detect AGEs is improved, but measurement precision deteriorates due to misalignment of excitation light irradiation locations

Engineering Contradiction:

ImproveAGEs detection capabilityVSAvoidmeasurement value consistency

Core Design Contradiction:

ReliabilityVSMeasurement precision

Solution Approach 1:

The measurement device incorporates an image capturing section that captures images of the irradiation location on the living body. The control section uses these captured images to calculate and determine the precise irradiation location, then feeds this information back to adjust the excitation light irradiation. This feedback loop ensures that the excitation light consistently targets the same specific location (such as blood vessels) across multiple measurements, eliminating misalignment issues and improving measurement precision while maintaining AGEs detection capability

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

The patent replaces manual or mechanical positioning methods with an optical imaging and computational approach. Instead of relying on physical alignment mechanisms or manual positioning of the excitation light source, the system uses an image capturing section to optically identify the irradiation location, and a control section with calculation capabilities to determine the precise coordinates. This substitution of mechanical positioning with optical-detection-and-computation methodology achieves higher precision and consistency in locating blood vessels and other target structures

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Ease of operation

If the excitation light irradiation location is not fixed, then the device can be operated more easily, but measurement precision deteriorates due to location variation

Engineering Contradiction:

Improvedevice operabilityVSAvoidirradiation location consistency

Core Design Contradiction:

Ease of operationVSMeasurement precision

Solution Approach 1:

The measurement device performs self-positioning through the image capturing section that automatically identifies and locates the target structure (such as blood vessels) on the living body. The control section automatically calculates the irradiation location based on the captured image, eliminating the need for manual positioning by the operator. This self-service mechanism maintains ease of operation while ensuring precise and consistent irradiation location, as the system autonomously finds and targets the correct anatomical structure

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

Before excitation light irradiation begins, the image capturing section预先 captures an image of the irradiation location, and the control section预先 calculates and determines the precise target coordinates. This preliminary action of identifying and locking onto the target location before measurement ensures that subsequent excitation light irradiation is consistently directed at the same specific structure, maintaining both ease of operation and measurement precision

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach reduces variation in measurement values by ensuring consistent irradiation of specific body locations, improving the reliability and reproducibility of AGEs detection, allowing for early identification of diabetes and monitoring of its progression.

Implementation Method 1

an excitation light irradiation section for irradiating a specific part or a specific location of a living body with excitation light; and a light receiving section for receiving fluorescence generated by irradiating the specific part or the specific location with the excitation light

Methodology Applied

Scientific EffectFluorescence: Fluorescence

Implementation Method 2

a light receiving section for receiving fluorescence generated by irradiating the specific part or the specific location with the excitation light

Methodology Applied

Scientific EffectFluorescence detection: Fluorescence

Data Source

PatentUS9173604B2Measurement device, measurement method, measurement result processing device, measurement system, measurement result processing method, control program, and recording medium

Publication Date: 2015.11.03 AIR WATER INC

AI summary

A measurement device (1) includes a probe (7) which irradiates a specific part or a specific location of a living body with excitation light and which receives fluorescence generated by irradiating the specific part or the specific location with excitation light.