Intra-tumoral Probe Wire for Sequential Agent Deployment

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Solution Overview

Problem

Current targeted therapies for lung cancer lack effective mechanisms for sequential deployment of therapeutic and binding agents directly to tumor tissues, leading to inefficient retention and exposure of the therapeutic agents.

Innovation Solution

A catheter system with a rotatable lumen arrangement and an intra-tumoral probe wire allows for precise targeting and sequential deployment of therapeutic agents and binding agents through a dual lumen system, enhancing retention and exposure by disrupting tumor tissue and forming an inlet for local delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If a single lumen catheter system is used for agent delivery, then the device structure is simple, but sequential deployment of therapeutic and binding agents cannot be achieved

Engineering Contradiction:

Improvecatheter structureVSAvoidsequential agent deployment capability

Core Design Contradiction:

Device complexityVSAdaptability or versatility

Solution Approach 1:

The catheter is divided into multiple lumens (first lumen and second lumen) within the elongated shaft assembly. The first lumen is dedicated for delivering therapeutic agents while the second lumen is dedicated for delivering binding agents, enabling sequential deployment without compromising structural simplicity

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The elongated shaft assembly with multiple lumens serves multiple functions: it provides a pathway for sequential agent delivery, maintains structural integrity, and enables both therapeutic and binding agent deployment through a single integrated device

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Ease of operation

If therapeutic agents are delivered without tumor tissue disruption, then the delivery method is simple, but retention and exposure of the therapeutic agent to the tumor is insufficient

Engineering Contradiction:

Improveagent delivery methodVSAvoidtherapeutic agent retention

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The probe wire is deployed to disrupt tumor tissue and form an inlet channel before the therapeutic agents are delivered through the lumens. This preliminary tissue disruption ensures proper agent placement and enhances subsequent retention and exposure

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The probe wire acts as an intermediary tool that creates the necessary tissue pathway and inlet for subsequent agent delivery. It mediates between the delivery system and the tumor tissue, enabling effective agent placement without requiring complex delivery mechanisms

Inventive Principle:

Principle #24Intermediary (Mediator)

3Device complexity

If therapeutic agents are delivered without binding agents, then the treatment protocol is simple, but the exposure time and retention of therapeutic agents at the tumor site is reduced

Engineering Contradiction:

Improvetreatment protocolVSAvoidtherapeutic agent exposure time

Core Design Contradiction:

Device complexityVSDuration of action of moving object

Solution Approach 1:

The binding agent is delivered sequentially after the therapeutic agent to maintain continuous presence of therapeutic substances at the tumor site. The binding agent prolongs the exposure time by anchoring the therapeutic agents, creating a continuous therapeutic effect without requiring separate treatment sessions

Inventive Principle:

Principle #20Continuity of useful action

Solution Approach 2:

The binding agent delivery lumen is nested within the same catheter system as the therapeutic agent lumen. The second lumen delivers binding agents that nestle around and secure the previously delivered therapeutic agents, creating a nested therapeutic configuration that extends exposure time

Inventive Principle:

Principle #7Nested doll (Nesting)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system enables precise and effective delivery of therapeutic agents directly to lung tumors, improving retention and exposure, thereby enhancing treatment efficacy while minimizing side effects.

Implementation Method 1

displacement of the intra-tumoral probe wire interposed there between or slidably disposed between any one of, or combination of the at least one lumen causes disruption of a tumor tissue and forms an inlet

Methodology Applied

Scientific EffectMechanical Force: Mechanical Force

Data Source

PatentUS10869996B2Method and apparatus for sequential deployment of intra-tumoral agents

Publication Date: 2020.12.22 KUPERBERG STEPHEN

AI summary

An intra-tumoral agent deployment apparatus for diagnosing and delivering targeted, sequential deployment of agents to an endo-bronchial and, or an intra-parenchymal tumor, said apparatus formed of, among other things, an elongated shaft assembly including: at least one lumen; an intra-tumoral probe wire for tumor traversal, slidably interposed there between or slidably disposed between any one of, or combination of the at least one lumen; and wherein the displacement of the intra-tumoral probe wire causes disruption of an endo-bronchial and, or an intra-parenchymal tumor tissue, and, or creating an inlet for deployment of at least a first agent comprising any one of a therapeutic agent and, or a delivery vehicle from the first lumen, and a subsequent second agent comprising any one of a therapeutic agent and, or a binding agent from any one of the first lumen, second lumen, and, or the delivery vehicle.