Probiotic Acne Composition Combining L. Rhamnosus and Spirulina
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Solution Overview
Problem
There is a need for probiotic compositions that provide a significant improvement in the treatment of acne, particularly using well-known grading systems such as the Global Acne Grading System (GAGS) or the Acne Global Severity Scale (AGSS).
Innovation Solution
A novel Maltodextrin-based formula containing a mixture of Lactobacillus rhamnosus CECT 30031 and Arthrospira platensis BEA_IDA_0074B (Spirulina paraca) strains is administered, which significantly improves acne symptoms when used in combination, as shown by a pilot study with patients with moderate acne vulgaris.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional acne medications (topical retinoids and benzoyl peroxide) are used, then acne treatment effect is achieved, but skin barrier function is disrupted causing irritation and dryness
Solution Approach 1:
The patent introduces probiotic strains (Lactobacillus rhamnosus and Arthrospira platensis) as intermediary substances that mediate between the harmful effects of conventional acne medications and the skin barrier. These probiotics modulate the skin microbiome and immune response, reducing irritation and dryness while maintaining acne treatment effectiveness, thus resolving the contradiction between treatment efficacy and skin barrier protection
Solution Approach 2:
The patent changes the physiological parameters of the skin microbiome by introducing specific probiotic strains. This alters the microbial composition and immune response parameters, enabling the skin to better tolerate conventional acne medications while maintaining barrier function. The probiotics modify the skin's physiological state to reduce harmful effects without compromising treatment effectiveness
2Device complexity
If single probiotic strain is used, then formulation simplicity is maintained, but treatment efficacy is limited
Solution Approach 1:
The patent merges two different probiotic strains (Lactobacillus rhamnosus CECT 30031 and Arthrospira platensis BEA_IDA_0074B) into a single formulation. This combination synergistically enhances the anti-inflammatory and barrier-restoring effects compared to single strains, thereby improving treatment efficacy while maintaining formulation simplicity. The synergistic interaction between the two strains resolves the contradiction by achieving better results without proportionally increasing complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of these strains results in a clinically relevant and statistically significant improvement in acne symptoms, with a 61.8% response in the probiotic group compared to 35.4% in the placebo group, and notable improvements in AGSS, number of inflammatory lesions, and patient subjective impressions.
Implementation Method 1
The term probiotic has been defined as 'living microorganisms which, when consumed in adequate amounts, confer a health effect on the host'
Implementation Method 2
oral probiotics have been shown to improve insulin sensitivity in animal models as well as regulate the release of inflammatory cytokines in the skin through their interaction with gut-associated lymphoid tissue
Implementation Method 3
several strains of Lactobacillus have been shown to have systemics anti-inflammatory effects. Studies have shown that Lactobacillus reuteri induces systemics anti-inflammatory cytokines, such as interleukin (IL)-10
Implementation Method 4
Oral ingestion of certain probiotic strains has been shown to improve the skin barrier and affect skin hydration and transepidermal water loss
Data Source
AI summary
Probiotic compositions are provided in the present invention that comprise bacterial strains L. rhamnosus CECT 30031 and bacterial strain Arthrospira platensis (Spirulina paraca). The disclosed probiotic compositions are useful in the treatment of acne.