Probiotic Additive Inhibits Pathogens via Synergistic Mixture
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Solution Overview
Problem
Existing probiotic food, feed, and drinking water additives that use broad spectra of intestinal bacteria face issues with undefined mixtures, such as antibiotic resistance transfer and regulatory compliance, and often fail to provide comprehensive inhibition of pathogenic germs like Salmonella, E. coli, and Clostridia across the entire digestive system.
Innovation Solution
A probiotic additive containing a defined mixture of microorganisms including Enterococcus faecium, Lactobacillus reuteri, Lactobacillus salivarius ssp. salivarius, Pediococcus acidilactici, and Bifidobacterium animalis, which are selected for their diverse origins and synergistic effects to inhibit a wide range of pathogenic germs, along with prebiotic substances and carriers for enhanced activity and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a broad spectrum of intestinal bacteria is used, then the field of application is widened and inhibition of pathogenic germs is enhanced, but undefined mixtures cause problems of antibiotic resistance transfer and regulatory compliance
Solution Approach 1:
The patent extracts only the essential and safe bacterial components (cell wall components, homogenates, or sterilized cells) from the complete bacterial organisms, thereby eliminating the risk of antibiotic resistance transfer and disease transmission while maintaining the beneficial competitive exclusion effect against pathogenic germs
Solution Approach 2:
The patent transforms the bacterial material through physical and chemical processing (sterilization, homogenization, cell wall extraction) to change its state from living organisms to inactivated forms, which eliminates reproductive risks while preserving the functional properties needed for pathogen inhibition
2Measurement precision
If individual specific bacteria or combinations are used, then activity against a special pathogenic germ is achieved, but the administered spectrum is not broad enough to achieve complete inhibition of pathogenic germs
Solution Approach 1:
The patent combines multiple bacterial species (Brevibacterium, Corynebacterium, and other safe intestinal bacteria) into a synergistic mixture that provides broad-spectrum activity against diverse pathogenic germs including Salmonella, E. coli, and Clostridia, thereby achieving both specificity and versatility
Solution Approach 2:
The patent creates a multi-functional probiotic formulation where the bacterial mixture provides simultaneous protection against multiple types of pathogenic germs through competitive exclusion, making a single product effective across various applications and animal species
3Stability of the object's composition
If bacteria are used as obtained without drying or concentration, then freshness is maintained, but problems of stability and applicability occur
Solution Approach 1:
The patent applies drying and concentration processes to transform the bacterial material into stable, easy-to-apply forms (powders, concentrates, or coated particles) that maintain their functional properties while improving shelf life, storage stability, and ease of incorporation into feed and water systems
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The additive achieves significant inhibition of pathogenic germs throughout the digestive system, including E. coli, Salmonella, and Clostridia, with a synergistic effect that enhances pH lowering and metabolic activity, ensuring effective competitive exclusion and immune system boosting without promoting antibiotic resistance.
Implementation Method 1
The use of such mixtures of microorganisms is based on what is called competitive exclusion (CE), by which it is attempted to suppress or eliminate 'bad' bacteria, i.e. health-impairing or harmful bacteria, by so-called 'good' bacteria. Thus, the growth of good bacteria inhibits that of bad bacteria
Implementation Method 2
a synergistic effect that enhances pH lowering and metabolic activity
Data Source
AI summary
The invention relates to a probiotic health or fitness promoting human or animal foodstuff and/or drinking water additive, comprising a mixture of microorganisms, selected from the group Enterococcus faecium, DSM 16211, Lactobacillus reuteri, DSM 16350, Lactobacillus salivarius ssp. salivarius, DSM 16351, Pediococcus acidilactici, DSM 16210, Bifidobacterium animalis and DSM 16284. The invention further relates to a use of the human or animal foodstuff and/or drinking water additive, in particular for prevention of the harmful effect of a number of undesirable germs in the digestive system of animals and/or domestic birds.