Probiotic Composition Modulating Allergic Inflammatory Activity
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Solution Overview
Problem
Current treatments for allergies, particularly seasonal allergies and related conditions, often come with side effects and do not provide long-term benefits, and there is a need for effective, side-effect-free alternatives that can modulate allergic-type inflammatory activity.
Innovation Solution
A probiotic composition comprising strains of Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium breve, which are administered orally or topically to modulate immune responses and reduce allergic inflammatory activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional treatments (corticosteroid nasal sprays, antihistamine drugs) are used to treat allergies, then allergic symptoms are relieved, but side effects occur (nasal bleeding, drowsiness, dry mouth, constipation, dizziness)
Solution Approach 1:
The patent uses probiotic bacteria as a temporary, self-limiting treatment approach. The probiotics are administered to modulate the immune system temporarily, providing relief without the cumulative side effects of conventional medications. The treatment is designed to be safe for long-term use with minimal adverse effects.
Solution Approach 2:
The probiotic composition acts as an intermediary between the allergen and the immune system. Instead of directly blocking allergen receptors like antihistamines, the probiotics modulate the immune response through microbial-metabolite-immune interactions, providing a gentler mediation that avoids the harsh side effects of direct pharmacological intervention.
2Duration of action of moving object
If spray decongestants are used for long-term relief, then allergic symptoms are managed, but no long-term benefit is provided and dependency may occur
Solution Approach 1:
The probiotic treatment works by preliminary modulation of the immune system before allergic reactions fully develop. By establishing a balanced immune response through probiotic administration, the body is better prepared to handle allergen exposure, providing both immediate and long-term benefits without dependency.
Solution Approach 2:
The probiotic composition provides continuous immune modulation through regular administration. Unlike spray decongestants that provide only temporary symptomatic relief, the probiotics continuously train and regulate the immune system, offering sustained benefit over time and potentially reducing the need for conventional medications.
3Reliability
If probiotic bacteria strains are used for immune support, then allergic inflammatory activity may be modulated, but scientific evidence is not sufficiently established and efficacy is conflicting
Solution Approach 1:
The patent uses a composite probiotic formulation containing multiple strains (Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium breve) rather than single strains. This composite approach synergistically enhances immune modulation effects and provides more robust scientific evidence through multi-strain interactions, addressing the conflicting results seen with individual strains.
Solution Approach 2:
The patent specifies precise parameters for probiotic administration including dosage ranges (10^8 to 10^11 CFU per day), treatment duration (at least 4 weeks), and specific strain combinations. These parameter standardizations make the effects measurable and reproducible, establishing clearer scientific evidence compared to variable probiotic treatments in previous studies.
Data Source
AI summary
The present invention relates to probiotic compositions comprising:—one or more strains belonging to the genus Lactobacillus selected from the species: Lactobacillus rhamnosus and Lactobacillus acidophilus; —one or more strains belonging to the genus Bifidobacterium selected from the species: Bifidobacterium longum and Bifidobacterium breve. —Such compositions are useful in modulating allergy-like inflammatory activity and, therefore, are compositions useful in the prevention and/or treatment of allergies, respiratory allergies, preferably seasonal allergies such as hay fever, allergic rhinitis, allergic rhinoconjunctivitis, and allergic asthma, or allergies related to Staphylococcus aureus and Clostridium difficile.