Probiotic Strains Metabolize Anthocyanins for Colon Delivery
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Solution Overview
Problem
The challenge lies in translating the health benefits of anthocyanins into effective interventions for preventing or treating conditions like cardiovascular diseases and metabolic disorders, as their effectiveness is hindered by interindividual variability in gut microbiota composition and activity, and direct delivery of their metabolites is not feasible.
Innovation Solution
A composition comprising specific probiotic strains from Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus mucosae, and Lactobacillus johnsonii, combined with anthocyanins, which are designed to produce ferulic acid, protocatechuic acid, and phloroglucinaldehyde metabolites, and utilize a colon-targeted release formulation to enhance metabolization by gut microbes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If anthocyanins are consumed to prevent or treat cardiovascular diseases and metabolic disorders, then health benefits are expected, but interindividual variability in gut microbiota composition and activity hinders effectiveness
Solution Approach 1:
The patent changes the parameter of microbiota composition by selecting specific probiotic strains (Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus mucosae, and Lactobacillus johnsonii) that are known to produce beneficial metabolites from anthocyanins. This standardization of microbial parameters reduces interindividual variability and ensures consistent production of ferulic acid, protocatechuic acid, and phloroglucinaldehyde, thereby improving the reliability of anthocyanin intervention effects.
2Reliability
If direct delivery of anthocyanin metabolites is used, then therapeutic effect is improved, but feasibility is reduced as direct delivery is not possible
Solution Approach 1:
The patent applies self-service by utilizing the gut microbiota's natural metabolic capability to convert anthocyanins into beneficial metabolites. Instead of requiring external delivery systems, the probiotic strains perform the transformation function themselves within the gut environment, making the system self-sufficient and feasible for oral supplementation.
Solution Approach 2:
The probiotic strains act as intermediary agents that facilitate the conversion of anthocyanins into bioactive metabolites. These strains serve as biological mediators between the anthocyanin substrate and the desired therapeutic effect, enabling the delivery of active metabolites through natural gastrointestinal processes rather than direct administration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the production of beneficial anthocyanin metabolites, overcoming variability in microbiota composition and ensuring targeted delivery to the colon, thereby improving health outcomes by promoting the production of ferulic acid, protocatechuic acid, and phloroglucinaldehyde, which can synergistically act to prevent or ameliorate conditions such as cardiovascular diseases and metabolic disorders.
Implementation Method 1
the majority of ingested polyphenols is not absorbed in its intact form but reaches the large intestine and is converted to absorbable metabolites by gut microbes
Implementation Method 2
O-deglycosylation of anthocyanidins to the respective anthocyanins by gut microbiota and by specific bacterial strains of e.g. the genus Lactobacillus
Data Source
AI summary
The current invention concerns preparations comprising at least one probiotic strain belonging to the species Lactobacillus helveticus, Lactobacillus rhamnosus (Lacticaseibacillus rhamnosus), Lactobacillus mucosae (Limosilactobacillus mucosae), and Lactobacillus johnsonii and anthocyanins.