Probiotic Anthocyanin Prebiotic Supplement Formulation
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Solution Overview
Problem
Probiotics administered orally often fail to colonize the intestine due to the hostile intestinal environment, leading to potential adverse effects in inflammatory diseases and interactions with antibiotics, and existing formulations may not provide consistent health benefits without these drawbacks.
Innovation Solution
A dietary supplement composition combining probiotic microorganisms with anthocyanins or plant extracts rich in anthocyanins, optionally with prebiotics, that are free of milk fermentation products, to enhance the health benefits of probiotics while minimizing adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If probiotics are administered orally to provide health benefits, then immune function and intestinal health are improved, but the bacteria fail to colonize the intestine due to the hostile intestinal environment and are eliminated from the body
Solution Approach 1:
The patent uses prebiotics as intermediary substances that mediate between the probiotics and the hostile intestinal environment. The prebiotics serve as food sources that protect and nourish the probiotic bacteria, enabling them to survive and colonize the intestine despite the harsh conditions including stomach acid and bile salts.
Solution Approach 2:
The invention creates a composite probiotic formulation that combines multiple types of bacteria (Lactobacillus, Bifidobacterium, Saccharomyces) with prebiotic substances. This composite approach enhances the overall survival and effectiveness of the probiotic mixture by providing diverse protective mechanisms and metabolic pathways.
2Reliability
If probiotics are administered to improve intestinal health, then benefits such as reduced Heliobacter pylori and relief from constipation are achieved, but adverse effects occur in inflammatory diseases where the mucosa epidermis becomes permeable allowing bacteria to enter the serum
Solution Approach 1:
The patent modifies the physiological parameters of the intestinal environment by introducing prebiotics that alter pH, nutrient availability, and microbial metabolism. These parameter changes create conditions that favor probiotic survival while reducing the risk of bacterial translocation, particularly in inflammatory conditions where mucosal integrity is compromised.
Solution Approach 2:
The probiotic formulation is designed to be self-protecting through the inclusion of prebiotics that automatically nourish and protect the bacteria upon ingestion. The prebiotics serve as an built-in protective mechanism that activates the probiotics' defensive capabilities without requiring external intervention, enabling them to withstand hostile environments and prevent harmful translocation.
3Reliability
If probiotics are administered during antibiotic medication, then the intention is to support intestinal flora regeneration, but the probiotics cannot settle in the intestine due to antibiotic interference
Solution Approach 1:
The prebiotics in the formulation provide preliminary protective action against antibiotic interference by creating a protective niche for the probiotics. The prebiotics are metabolized by the probiotics into protective substances that neutralize or reduce the impact of antibiotics, allowing the probiotics to survive and colonize even during antibiotic therapy.
4Ease of operation
If milk fermentation products are used as probiotic carriers, then probiotic delivery is achieved, but the composition is not suitable for individuals with lactose intolerance or milk allergies
Solution Approach 1:
The patent extracts the probiotic bacteria from their traditional milk fermentation carrier and formulates them in a milk-free base. This extraction allows the probiotics to be delivered without the lactose and milk proteins that cause intolerance and allergies, while maintaining the beneficial probiotic effects. The probiotics are preserved and delivered using alternative carriers that do not contain milk components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of probiotics and anthocyanins shows synergistic health benefits, reducing toxic metabolism products and improving probiotic performance, with prebiotics enhancing stability and effectiveness, thereby providing improved intestinal health benefits without the drawbacks of traditional probiotic administration.
Implementation Method 1
anthocyanins, which show a strong anti-oxidative effect, improve the performance of probiotic bacteriae
Implementation Method 2
with prebiotics enhancing stability and effectiveness
Data Source
AI summary
Suggested is a dietary supplement composition, comprising (a) at least one probiotic micro-organism and (b) at least one anthocyanin or a plant extract or a fruit juice comprising anthocyanins, and optionally (c) at least one prebiotic on condition that the compositions are free of milk fermentation products.