Probiotic Composition for Anti-Aging via Oxidative Stress Reduction
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Solution Overview
Problem
Current anti-aging solutions, such as resveratrol, have side effects and safety concerns, and there is a need for a safe and effective anti-aging supplement that can be chronically taken, particularly in geriatric healthcare.
Innovation Solution
An anti-aging composition comprising isolated lactic acid bacterial strains or their fermented products, specifically Bifidobacterium bifidum VDD088, Bifidobacterium breve Bv-889, and Bifidobacterium longum BLI-02, which can be administered in food, pharmaceutical, or cosmetic forms to scavenge free radicals, inhibit P21 gene expression, and reduce oxidative stress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If resveratrol is used for anti-aging, then anti-oxidation property is improved, but side effects occur
Solution Approach 1:
The patent uses lactic acid bacteria as a safe, chronically administrable alternative to resveratrol. The bacteria provide sustained anti-aging benefits through continuous probiotic action in the gut, replacing the need for high-dose resveratrol supplementation that causes side effects.
Solution Approach 2:
The patent introduces lactic acid bacteria as an intermediary substance that mediates anti-aging effects through gut microbiota modulation. The bacteria produce metabolites and interact with the host immune system to achieve anti-oxidation and anti-senescence effects without the direct toxic effects of resveratrol.
2Object-affected harmful factors
If probiotics are used for anti-aging, then safety is improved, but anti-aging function needs to be enhanced
Solution Approach 1:
The patent uses a composite of three different lactic acid bacterial strains (Bifidobacterium bifidum, Bifidobacterium breve, and Bifidobacterium longum) to achieve synergistic anti-aging effects. Each strain contributes different beneficial properties, and their combination provides enhanced anti-oxidation and anti-senescence functions compared to single strains.
Solution Approach 2:
The patent combines multiple lactic acid bacteria strains with different anti-aging mechanisms into a single probiotic composition. This merging of strains allows the composition to address multiple aging pathways simultaneously while maintaining safety through the well-established safety profile of probiotics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively prevents aging by scavenging free radicals, reducing protein carbonyl contents, enhancing catalase activity, and lowering 8-oxo-2′-deoxyguanosine levels, demonstrating anti-aging activity in vitro and in vivo without the side effects associated with existing compounds.
Implementation Method 1
reactive oxygen species can destruct intracellular molecules in a body... oxidation materials are related to cardiovascular disease, cancer, and aging... lactic acid bacteria or the fermented product thereof... scavenge free radicals, reducing protein carbonyl contents, enhancing catalase activity, and lowering 8-oxo-2'-deoxyguanosine levels
Implementation Method 2
lactic acid bacteria or the fermented product thereof... some probiotic strains have the activity of anti-oxidation
Data Source
AI summary
The present invention discloses an anti-aging composition, which includes: (a) isolated lactic acid bacterial strains or a fermented product thereof; and (b) an excipient, a diluent, or a carrier; wherein the isolated lactic acid bacterial strains include: Bifidobacterium bifidum VDD088 strains, Bifidobacterium breve Bv-889 strains, and Bifidobacterium longum BLI-02 strains. The present invention further provides a method for preventing aging by administering the foregoing anti-aging composition to a subject in need thereof.