Probiotic-Antioxidant Composition for Major Depression and Neuroprotection

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Solution Overview

Problem

Existing antidepressant treatments for major depressive disorder have low efficacy in 30% of patients, significant side effects, and fail to address neurodegeneration and neuroplasticity issues, necessitating new therapeutic strategies that reduce symptoms and improve quality of life without relapse.

Innovation Solution

A composition comprising specific probiotic bacteria strains (Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium longum) combined with vitamins (C, E, B9, D3), organic salts (magnesium, selenium, zinc), and antioxidants (N-acetyl cysteine, CoQ10, acetyl-L-carnitine) to regulate immune response and reduce inflammation, promoting neuroprotection and mitochondrial function.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional antidepressant drugs are used, then some depressive symptoms are relieved, but side effects occur and 30% of patients do not respond

Engineering Contradiction:

Improveantidepressant efficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines multiple probiotic strains (Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium longum) with specific vitamins (C, E, B9, D3), organic salts (magnesium, selenium, zinc), and antioxidants (N-acetyl cysteine, CoQ10, acetyl-L-carnitine) to create a composite formulation that addresses depression through multiple mechanisms simultaneously, reducing reliance on conventional drugs with side effects

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent changes the therapeutic approach from monoaminergic modulation to immune system regulation and inflammation reduction, fundamentally altering the treatment parameters by targeting cytokine levels, oxidative stress markers, and neuroplasticity factors instead of traditional neurotransmitter systems

Inventive Principle:

Principle #35Parameter changes

2Reliability

If conventional antidepressant treatments are used, then some symptoms are treated, but neurodegeneration and reduced neuroplasticity are not addressed

Engineering Contradiction:

Improvesymptom reliefVSAvoidneuroplasticity

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The probiotic bacteria act as intermediaries between the gut microbiota and the central nervous system, modulating immune responses and reducing inflammation that contribute to neurodegeneration, while vitamins and antioxidants serve as mediators to protect neuronal health and enhance neuroplasticity

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The composition enables the body's own immune system and neuroplasticity mechanisms to function optimally by providing necessary nutrients (vitamins, minerals) and reducing oxidative stress, allowing endogenous repair and protective processes to occur without continuous external drug intervention

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces depressive symptoms, improves mood, decreases anxiety, and enhances emotional well-being by rebalancing the immune system and reducing oxidative stress, offering a safer alternative to conventional treatments.

Implementation Method 1

Methodology Applied

Scientific EffectProbiotic modulation of immune response:

Implementation Method 2

antioxidants (N-acetyl cysteine, CoQ10, acetyl-L-carnitine) to regulate immune response and reduce inflammation, promoting neuroprotection and mitochondrial function

Methodology Applied

Scientific EffectAntioxidant activity: Oxidation

Implementation Method 3

CoQ10, acetyl-L-carnitine) to regulate immune response and reduce inflammation, promoting neuroprotection and mitochondrial function

Methodology Applied

Scientific EffectMitochondrial electron transport:

Data Source

PatentEP3496733B1Composition for use in the treatment of major depressive disorder

Publication Date: 2025.07.23 PROBIOTICAL SPA

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AI summary

This invention relates to a composition for use in the treatment of major depressive disorder. In addition, this invention relates to a composition for use in the treatment and/or improvement of mood disturbances and for use in the treatment and/or improvement of the mood state.