Probiotic Composition for Atopic Dermatitis via Immunomodulation
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Solution Overview
Problem
Current treatments for atopic dermatitis and allergies are limited by contraindications and poor tolerance in some patients, lacking definitive efficacy and failing to effectively address skin inflammation and symptom reduction.
Innovation Solution
A composition comprising specific probiotic bacterial strains, such as Lactobacillus salivarius (LS01), Bifidobacterium breve (BR03), Lactobacillus pentosus (LPS01), Streptococcus thermophilus (FP4), Lactobacillus casei ssp. rhamnosus (LR04), and Lactobacillus acidophilus (LA02), which are immunomodulating, capable of colonizing the intestinal tract, and administered in various forms to modulate the immune system and reduce inflammatory cytokines.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If drug-based treatments are used for atopic dermatitis, then some symptoms can be mitigated, but contraindications and poor tolerance limit their use
Solution Approach 1:
The patent introduces probiotic bacteria as an intermediary substance that mediates the treatment of atopic dermatitis through immunomodulation. These probiotics act as a bridge between the patient's immune system and the desired therapeutic effect, avoiding direct pharmacological intervention that causes side effects. The probiotics modulate immune responses indirectly by influencing cytokine production and immune cell activity, thereby treating the condition without the harmful effects of conventional drugs.
2Ease of operation
If conventional treatments are administered, then some symptoms are relieved, but definitive efficacy is lacking and symptoms recur
Solution Approach 1:
The patent applies preliminary action by administering probiotics before the onset of severe symptoms or during early stages of atopic dermatitis. The probiotics establish themselves in the patient's microbiota and immune system in advance, creating a protective immunomodulatory effect that prevents symptom recurrence rather than merely relieving symptoms after they appear. This proactive approach addresses the root immune dysregulation before it manifests as severe clinical symptoms.
3Reliability
If probiotic compositions are used, then immunological parameters improve, but specific bacterial strains and compositions must be selected
Solution Approach 1:
The patent applies parameter changes by optimizing specific characteristics of the probiotic composition, including the selection of particular bacterial strains (such as Lactobacillus and Bifidobacterium species), their ratios, viability counts, and formulation parameters. By systematically adjusting these parameters, the patent identifies optimal compositions that deliver reliable immunological effects while managing the complexity of formulation through evidence-based standardization.
Data Source
AI summary
The present invention relates to a composition comprising probiotic bacteria for the treatment of pathologies associated with alterations of the immune system. In particular, the present invention relates to the use of selected probiotic bacteria for the preparation of a composition for the treatment of allergies, such as atopic dermatitis.