Probiotic Bacteria Modified Carbohydrate Metabolism
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Solution Overview
Problem
Current technologies fail to effectively regulate carbohydrate metabolism and treat associated disorders, which have reached epidemic proportions due to unbalanced caloric intake leading to health issues such as obesity and undernutrition.
Innovation Solution
Development of probiotic compositions with modified carbohydrate metabolism, achieved through starch-stress directed evolution of probiotic bacteria, which alter glucose production and absorption, allowing for regulation of body weight and treatment of carbohydrate metabolism disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If probiotic bacteria are used to regulate carbohydrate metabolism, then glucose production and absorption are modified, but the ability to effectively treat carbohydrate metabolism disorders and regulate body weight is insufficient
Solution Approach 1:
The patent applies parameter changes by modifying the carbohydrate metabolism parameters of probiotic bacteria through directed evolution. The bacteria are evolved to produce altered amounts of glucose and modify carbohydrate absorption, thereby changing the metabolic parameters to effectively treat carbohydrate metabolism disorders and regulate body weight.
Solution Approach 2:
The probiotic bacteria perform self-service by autonomously regulating their own carbohydrate metabolism through directed evolution. The bacteria naturally adapt and modify their metabolic pathways to reduce glucose production and alter carbohydrate absorption, enabling them to self-regulate and treat metabolic disorders without external intervention.
2Reliability
If starch-stress directed evolution is applied to probiotic bacteria, then modified carbohydrate metabolism is achieved, but the complexity of the development process increases
Solution Approach 1:
The patent applies preliminary action by pre-applying starch-stress directed evolution to probiotic bacteria before they are administered to subjects. This preliminary evolutionary modification ensures that the bacteria already possess the desired modified carbohydrate metabolism capabilities when introduced to the host, simplifying the overall treatment process and reducing the complexity of subsequent interventions.
Data Source
AI summary
The present disclosure relates to probiotics and probiotic compositions having modified carbohydrate metabolism (e.g., modifying or metabolizing carbohydrates, or reduced glucose production), and thus regulating the absorption of the carbohydrates by the host subject. The present disclosure also relates to methods of making the probiotics and probiotic compositions. The present disclosure further relates to methods of regulating body weight in a subject, and methods of treating carbohydrate metabolism disorder, using the probiotics and probiotic compositions disclosed herein.