Phospholipid and Aloe Vera Probiotic Coating for GI Survivability
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Solution Overview
Problem
Existing probiotic products face challenges with high production costs, stability issues due to multi-process coating methods, and reduced efficacy from gastric acid and bile acid exposure, leading to potential side effects and decreased gastrointestinal survivability.
Innovation Solution
A coated probiotic using milk-derived phospholipid and Aloe vera gel as coating agents to enhance acid tolerance, bile tolerance, and storage stability, produced through a simplified process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multi-process coating methods are used to protect probiotics, then gastrointestinal survivability is improved, but manufacturing complexity and production cost increase
Solution Approach 1:
The patent combines multiple protective functions into a single coating layer comprising phospholipid and polysaccharide. This unified coating structure provides both acid tolerance and bile tolerance simultaneously, eliminating the need for separate multi-step coating processes while maintaining gastrointestinal survivability.
Solution Approach 2:
The coating layer uses a composite material system consisting of phospholipid and polysaccharide working together. The phospholipid provides acid tolerance through its amphipathic nature, while the polysaccharide contributes to bile tolerance and structural stability, creating a synergistic protective effect.
2Reliability
If high concentration of probiotic strain is used, then product efficacy is improved, but product price and consumer burden increase
Solution Approach 1:
The patent uses inexpensive natural materials (phospholipid from soybean or egg yolk, and common polysaccharides) for the coating layer. These materials are cost-effective alternatives to expensive commercial coating agents, reducing production costs while providing adequate protection.
Solution Approach 2:
The patent optimizes the ratio of phospholipid to polysaccharide in the coating layer to achieve maximum protective effect at minimum cost. By adjusting these compositional parameters, the formulation achieves cost-effective protection without requiring high concentrations of expensive probiotic strains.
3Stability of the object's composition
If additional coating processes are added, then probiotic stability is improved, but unit price and production cost increase
Solution Approach 1:
The coating layer is divided into two functional components with distinct roles: phospholipid for acid environment protection and polysaccharide for bile environment protection. This segmentation allows each component to be optimized for its specific function while being manufactured in a single integrated process.
Solution Approach 2:
The phospholipid acts as an intermediary substance that forms a protective barrier between the probiotic cells and the harsh gastric acid environment. Its amphipathic structure allows it to interface with both the aqueous gastric environment and the bacterial cell surface, providing effective protection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The coated probiotic demonstrates improved survival rates under simulated digestive conditions and extended storage stability, reducing production costs and minimizing gastrointestinal stress.
Implementation Method 1
a coated probiotic including: a probiotic; and a coating agent composed of milk-derived phospholipid and Aloe vera gel
Implementation Method 2
the bacteria themselves constituting the probiotics are composed of proteins and hence the cell membranes thereof are damaged by gastric acid and bile acid when the probiotics are taken into the body
Implementation Method 3
enhanced acid tolerance, bile tolerance, gastrointestinal survivability, cold storage stability and room temperature storage stability
Data Source
AI summary
The present disclosure relates to a coated probiotic having enhanced acid tolerance, bile tolerance, gastrointestinal survivability, cold storage stability and room temperature storage stability by including milk-derived phospholipid and Aloe vera gel as a coating agent, a food composition containing the same, and a method for producing the same. As the coated probiotic includes the Aloe vera gel and the milk-derived phospholipid as the coating agent, it may have increased stabilities against external environmental stress, such as lyophilization stability and storage stability of the probiotic itself, and may have significantly enhanced acid tolerance and bile tolerance which are the indices of the gastrointestinal stability of the probiotic after taking.