Probiotic Combination for Body Composition Improvement
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Solution Overview
Problem
Current probiotics have varying effects on weight loss and body composition due to distinct mechanisms of different bacterial strains, and combinations of strains often show worse or no significant effect compared to single strains, necessitating the identification of effective strains for obesity correction.
Innovation Solution
A combination of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198, administered in specific dosages, which are formulated into various food and supplement forms, to improve body composition by promoting weight loss, reducing visceral fat, and altering intestinal microbiota.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single probiotic strain is used, then the intestinal microbiota can be adjusted, but the effect on weight loss and body composition is insufficient
Solution Approach 1:
The patent combines multiple probiotic strains (Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198) into a single composition to achieve synergistic effects that enhance weight loss and body composition improvement beyond what single strains can accomplish alone
Solution Approach 2:
The patent creates a composite probiotic formulation containing specific ratios of different bacterial strains, where the combined effect of L. paracasei S38 and B. coagulans BC198 produces superior anti-obesity effects compared to individual strains
2Adaptability or versatility
If combinations of bacterial strains are used, then the functions of multiple strains can be achieved, but the effect on obesity correction is often worse or no significant improvement compared to single strains
Solution Approach 1:
The patent optimizes the dosage parameters of each probiotic strain in the combination, using low dosage of S38 (1×10^8 to 1×10^10 CFU/day) and low dosage of BC198 (1×10^8 to 1×10^10 CFU/day), where the specific parameter combination produces synergistic anti-obesity effects rather than antagonistic interactions
3Adaptability or versatility
If distinct probiotic strains are used, then different mechanisms can be targeted, but the interactions between strains may reduce overall effectiveness
Solution Approach 1:
The patent utilizes the feedback mechanism where butyric acid produced by the probiotic combination promotes the growth of beneficial bacteria (Akkermansia muciniphila and Ruminococcaceae), creating a positive feedback loop that enhances the overall effectiveness of the treatment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198 demonstrates synergistic effects in inhibiting lipogenesis, reducing body fat, and increasing butyric acid production, effectively addressing obesity by promoting weight loss and improving body composition.
Implementation Method 1
generation of butyric acid at intestinal environment
Implementation Method 2
counts of Akkermansia muciniphila and Ruminococcaceae within intestinal tracts
Implementation Method 3
inhibiting lipogenesis in adipocytes
Data Source
AI summary
A combination of probiotics for improving body compositions includes Lacticaseibacillus paracasei S38 and Bacillus coagulans BC198. The combination of probiotics can be a medicine composition, a nutrient supplement, healthy food or a combination thereof. The applications of the combination of probiotics include weight loss, reduction of fat, abatement of appetite, production of butyric acid within intestinal tracts and an increased count of Akkermansia muciniphila or Ruminococcaceae inside intestines.