Probiotic Composition for IBD and IBS Treatment
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Solution Overview
Problem
Current treatments for inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS) have limitations, including side effects from existing medications and modest efficacy, highlighting the need for more effective therapies that address bowel inflammation and gastrointestinal health.
Innovation Solution
A novel probiotic composition comprising specific strains of Lactobacillus plantarum and Pediococcus acidilactici, which are effective in reducing inflammation and improving gastrointestinal health by inhibiting pathogenic bacteria, promoting a balanced gut microbiota, and producing short-chain fatty acids, thereby alleviating symptoms of IBD and IBS.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional medications (5-ASA, corticosteroids, immunomodulatory medicaments) are used to treat IBD, then inflammation is reduced and symptoms are controlled, but serious side effects occur including bone mass reduction, infection risk, diabetes, muscle wasting, and immune suppression
Solution Approach 1:
The patent introduces probiotic bacteria (Lactobacillus plantarum and Bifidobacterium strains) as intermediary organisms that mediate the treatment of IBD through biological mechanisms rather than direct pharmacological action. These probiotics compete with pathogenic bacteria, produce antimicrobial substances, and modulate the immune system naturally, thereby controlling inflammation without the harmful side effects of conventional medications.
Solution Approach 2:
The probiotic composition enables the patient's own gastrointestinal system to fight inflammation through beneficial bacteria that restore microbial balance. The probiotics self-regulate by competing with harmful bacteria for resources and space, producing their own antimicrobial compounds, and stimulating the host's immune system to maintain remission without requiring external pharmaceutical intervention.
2Object-affected harmful factors
If probiotics are used to treat IBD and IBS, then gastrointestinal health is improved with minimal side effects, but the efficacy is modest compared to conventional medications
Solution Approach 1:
The patent combines multiple probiotic strains (Lactobacillus plantarum and Bifidobacterium species) into a single composition to achieve synergistic effects. Each strain contributes different beneficial properties such as antimicrobial production, immune modulation, and barrier function enhancement, collectively providing superior efficacy compared to single-strain probiotics or conventional medications alone.
Solution Approach 2:
The probiotic composition functions as a composite biological material where different bacterial strains work together to provide multifaceted therapeutic effects. The combination includes strains with complementary mechanisms of action, creating a more effective and balanced treatment that addresses various aspects of IBD and IBS pathophysiology simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The probiotic composition significantly reduces acute and chronic cytokines, improves clinical symptoms, and enhances the quality of life for patients with IBD and IBS by promoting a balanced gut microbiota and reducing inflammation, with minimal side effects.
Implementation Method 1
producing short-chain fatty acids
Data Source
AI summary
The present disclosure is directed to methods of administering and compositions comprising Lactobacillus plantarum CECT 7478, Lactobacillus plantarum CECT 7485, and Pediococcus acidilactici CECT 7483 or a mutant or variant thereof. The compositions and methods are useful in the probiotic treatment of bowel diseases or conditions such as Inflammatory Bowel Disease, Irritable Bowel Syndrome, and abdominal distension and bloating.