Multi-Strain Probiotic Composition for Recurrent Bacterial Vaginosis

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Solution Overview

Problem

Current treatments for bacterial vaginosis (BV) face issues of antibiotic resistance and high recurrence rates, with existing live bacterial drugs showing limited therapeutic effects and recurrence rates ranging from 30% to 54% within months.

Innovation Solution

A probiotic composition comprising Lactobacillus johnsonii, Lactobacillus gasseri, Lactobacillus crispatus, and Lactobacillus jensenii is administered to improve vaginal health, either alone or in combination with antibiotics, to enhance therapeutic efficacy and reduce recurrence.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If antibiotics are used for treating bacterial vaginosis, then the therapeutic effect is achieved quickly, but the recurrence rate increases to 30%-50% within 3 months

Engineering Contradiction:

Improvetherapeutic effect speedVSAvoidrecurrence rate

Core Design Contradiction:

SpeedVSReliability

Solution Approach 1:

The treatment is divided into two phases: acute phase using antibiotics for rapid symptom relief, and maintenance phase using probiotics to prevent recurrence. This segmentation allows each treatment modality to address specific aspects of the disease at appropriate times.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Probiotics are administered before and after antibiotic treatment to prepare the vaginal flora for resistant conditions and to restore beneficial bacteria after antibiotic-induced depletion. This preliminary and follow-up action prevents the recurrence of BV.

Inventive Principle:

Principle #10Preliminary action

2Speed

If antibiotics are used for treating bacterial vaginosis, then symptoms are relieved quickly, but antibiotic resistance develops with metronidazole resistance rate reaching 63.8%-67%

Engineering Contradiction:

Improvesymptom relief speedVSAvoidantibiotic resistance

Core Design Contradiction:

SpeedVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful effect of antibiotic resistance into a beneficial strategy by using probiotics as an alternative treatment approach. The probiotics restore vaginal flora balance and provide therapeutic effects without contributing to or overcoming antibiotic resistance.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

Probiotics serve as an intermediary treatment between antibiotic therapy and the vaginal microenvironment. They mediate the restoration of vaginal flora balance and provide continuous protective effects without the resistance issues associated with repeated antibiotic use.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stability of the object's composition

If live bacterial drugs are used for treating bacterial vaginosis, then vaginal flora balance is improved, but the cure rate remains limited at around 18.52%-24.44%

Engineering Contradiction:

Improvevaginal flora balanceVSAvoidcure rate

Core Design Contradiction:

Stability of the object's compositionVSReliability

Solution Approach 1:

The patent combines multiple probiotic strains (Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus johnsonii, and Lactobacillus jensenii) into a composite formulation that synergistically restores vaginal flora balance and achieves higher cure rates compared to single-strain preparations.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The probiotic formulation uses a composite approach by incorporating four different Lactobacillus strains, each contributing different functional properties. This composite probiotic preparation enhances the overall therapeutic effect and restores vaginal microecology more effectively than single-strain drugs.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The probiotic composition significantly improves the clinical cure rate to over 90% and reduces recurrence rates to less than 10%, offering a safer and more effective treatment for BV.

Implementation Method 1

Lactobacillus, as the dominant vaginal flora, inhibits pathogen adhesion by producing lactic acid to maintain an acidic environment (pH 3.8-4.5)

Methodology Applied

Scientific EffectLactic acid production: Fermentation

Implementation Method 2

Lactobacillus, as the dominant vaginal flora, inhibits pathogen adhesion by producing lactic acid to maintain an acidic environment (pH 3.8-4.5), generating H2O2 and bacteriocins

Methodology Applied

Scientific EffectHydrogen peroxide generation: Fermentation

Implementation Method 3

supplementation with exogenous lactobacilli (e.g., Lactobacillus crispatus and Lactobacillus gasseri) can significantly improve the vagina's ability to regulate pH and maintain the vaginal microenvironment

Methodology Applied

Scientific EffectProbiotic action: Fermentation

Data Source

PatentUS20260014216A1Use of probiotic composition in preparation of formulation for improving vaginal health

Publication Date: 2026.01.15 SICHUAN ANAEROBIC BIOTECHNOLOGY CO LTD

AI summary

The present disclosure provides use of a probiotic composition comprising active ingredients including Lactobacillus johnsonii, Lactobacillus gasseri, Lactobacillus crispatus, and Lactobacillus jensenii in the preparation of a microbial formulation, wherein the microbial formulation is used for: improving the therapeutic effect of an additional drug for treating bacterial vaginosis in the treatment of bacterial vaginosis; improving the prognosis of bacterial vaginosis treated with an additional drug for treating bacterial vaginosis; treating, preventing, mitigating, and/or controlling the recurrence of bacterial vaginosis in a subject; treating, preventing, mitigating, and/or controlling atrophic vaginitis in a subject; improving the Nugent score of a subject; or ameliorating vaginal dryness in a subject.