Probiotic Composition for Dry Sensitive Skin via Gut-Skin Axis
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Solution Overview
Problem
Current treatments for dry and sensitive skin conditions such as psoriasis, atopic dermatitis, and ichthyosis are limited in effectiveness and often come with significant side effects, with a lack of understanding in the molecular mechanisms behind their impact on skin health.
Innovation Solution
A composition comprising a blended population of probiotic bacterial species, including Bifidobacterium animalis, Lactobacillus brevis, Lactobacillus reuteri, and Lactococcus lactis, which decreases the levels of pro-inflammatory interleukins (IL-17 and IL-23) and increases anti-inflammatory interleukin-10, thereby improving gut barrier function and skin health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for dry and sensitive skin conditions, then skin symptoms are addressed, but significant side effects occur and effectiveness is limited
Solution Approach 1:
The patent introduces probiotic bacteria as an intermediary agent that mediates the treatment of skin conditions through the gut-skin axis. Instead of directly applying treatments to the skin, the probiotics are administered orally to modulate gut microbiota, which in turn affects skin health through immune system regulation and reduction of systemic inflammation, thereby reducing side effects while maintaining effectiveness
Solution Approach 2:
The patent replaces conventional topical or systemic pharmacological interventions with a biological approach using probiotic bacteria. This substitution shifts from chemical/mechanical treatment mechanisms to biological mechanisms, utilizing the probiotics' ability to modulate immune responses and reduce inflammation through natural biological pathways, thereby reducing harmful side effects
2Object-affected harmful factors
If probiotic bacteria are administered to treat skin conditions, then side effects are reduced, but the molecular mechanisms are not fully understood
Solution Approach 1:
The patent employs feedback mechanisms by measuring changes in gut microbiota composition and skin condition parameters before and after probiotic administration. This feedback loop allows for optimization of treatment protocols and provides data that can inform future research into the molecular mechanisms, gradually filling the information gap through systematic observation and measurement
Data Source
AI summary
The present invention relates to a composition for use in the treatment and/or prevention of a dry and/or sensitive skin condition in a subject. The composition comprises at least two bacterial species which decrease the levels of interleukin-17 and/or interleukin-23 in the subject, and/or increase the levels of interleukin-10 in the subject and/or improve gut barrier function in the subject. The at least two bacterial species may comprise Bifidobacterium animalis, Lactobacillus brevis, Lactobacillus reuteri and/or Lactococcus lactis.