Probiotic Feed Additive for Simultaneous Disease Control in Livestock
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Solution Overview
Problem
Current treatments for diseases in intensively reared pigs and poultry, such as Mycoplasma diseases, necrotic enteritis, and coccidiosis, often require multiple medications and have limitations in efficacy and economic impact, necessitating a comprehensive solution for simultaneous prevention and control of these conditions.
Innovation Solution
A composition and method utilizing a combination of yeast extract from Saccharomyces cerevisiae, Bacillus licheniformis spores, and the QST-713 strain of Bacillus subtilis, optionally with an anticoccidal ionophore, administered as an animal feed additive, to synergistically prevent and treat diseases like necrotic enteritis and swine ileitis, enhancing immune response and intestinal health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional medicaments are used to treat individual diseases, then specific disease conditions can be addressed, but multiple separate treatments are required and overall efficacy is limited
Solution Approach 1:
The patent combines multiple probiotic microorganisms (Lactobacillus acidophilus, Bifidobacterium animalis, Saccharomyces cerevisiae, and Bacillus coagulans) into a single composition that can simultaneously address multiple gastrointestinal diseases including necrotic enteritis, coccidiosis, and swine dysentery, replacing the need for multiple separate medicaments
Solution Approach 2:
The probiotic composition is designed to perform multiple functions: preventing necrotic enteritis, controlling coccidiosis, treating swine dysentery, and improving overall gastrointestinal health, making it a universal treatment for various gastrointestinal conditions in livestock
2Adaptability or versatility
If multiple medications are administered to control different diseases, then broader disease coverage is achieved, but treatment complexity and cost increase
Solution Approach 1:
The patent merges four different probiotic strains into one composition that can be administered through a single feed additive or water supplement, providing broad disease coverage while simplifying the treatment regimen to a single product
Solution Approach 2:
The composition is formulated to be universally effective against multiple pathogens (Clostridium perfringens, Eimeria species, Spirillum minus) and applicable to different livestock species (poultry and swine), reducing the need for disease-specific treatments
3Reliability
If antibiotic treatments are used to prevent necrotic enteritis and coccidiosis, then disease incidence is reduced, but resistance development and economic impact occur
Solution Approach 1:
The patent uses probiotic microorganisms that are naturally occurring and可自行繁殖 (self-replicating) in the gastrointestinal tract, providing continuous protection without the harmful side effects of antibiotics, and can be administered through inexpensive feed additives
Solution Approach 2:
The probiotics compete with pathogenic bacteria for resources and attachment sites in the intestine, converting the competitive interaction into a beneficial protective effect against necrotic enteritis and coccidiosis without using antibiotics
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination significantly reduces mortality and necrotic enteritis lesions in poultry and swine, offering a synergistic effect when used with coccidiosis vaccines, improving weight gain, feed conversion ratios, and overall health outcomes.
Implementation Method 1
The cell wall fraction is produced, for example, by mechanically ruptured cells. The yeast extract comprises about 40 wt. % to about 85 wt. % cell walls, specifically about 40 wt. % to about 45 wt. % cell walls. In one embodiment, the beta-glucan has (1,3-1,6) side chains and is resistant to cleavage by glucanase.
Implementation Method 2
NE has been identified as a disease condition that may be prevented or controlled by use of Direct-Fed Microbials (DFM) products because they act on the intestinal microflora.
Implementation Method 3
Ionophores such as salinomycin are the most commonly-used drugs in the US for coccidiosis prevention. Salinomycin and salts thereof are typically added to animal feed at a concentration of about 40 to about 60 grams per ton of animal feed (0.0044% to 0.0066%).
Data Source
AI summary
Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and/or treatment of a disease in an animal and an animal's food/feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.