Probiotic Composition with Lactoferrin and Prebiotics for Gut Survival
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Solution Overview
Problem
Current probiotic compositions face challenges in surviving manufacturing processing and transit through the gastrointestinal tract, leading to reduced efficacy in maintaining intestinal health and addressing dysbioses caused by stress, dietary imbalances, and antibiotic treatments.
Innovation Solution
A probiotic composition comprising Bifidobacterium longum, Lactobacillus helveticus, and Lactobacillus plantarum, combined with a carrier containing prebiotics like inulin and fructose, mineral salts, lactoferrin, and glutathione, which enhances the survival and colonization of probiotics in the gut, providing anti-inflammatory and immunomodulating effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If probiotics are administered in traditional formulations, then they can be delivered to the host, but their survival through manufacturing processing and gastrointestinal transit is reduced
Solution Approach 1:
The patent uses a protective carrier system comprising prebiotics (inulin, fructose), mineral salts (magnesium gluconate, zinc gluconate, potassium citrate), lactoferrin, and glutathione as intermediary substances that shield probiotic bacteria from harmful environmental factors during manufacturing and gastrointestinal transit, thereby enhancing their survival without altering the probiotics themselves
Solution Approach 2:
The invention creates a composite probiotic formulation by combining probiotic bacteria with a multi-component carrier system containing prebiotics, mineral salts, lactoferrin, and glutathione. This composite structure provides synergistic protection, where each component contributes to enhancing probiotic survival through different mechanisms (nutritional support, antioxidant protection, immune modulation)
2Reliability
If probiotics are used to maintain intestinal health, then they can address dysbioses, but their efficacy is reduced due to poor survival and colonization
Solution Approach 1:
The carrier components, particularly prebiotics and mineral salts, are included in the formulation beforehand to prepare a favorable environment in the gastrointestinal tract before the probiotics need to colonize. This preliminary action ensures that when probiotics arrive, they immediately encounter supportive conditions that enhance their survival and colonization capabilities
Solution Approach 2:
The invention modifies the chemical and biological parameters of the gastrointestinal environment through the carrier system. Lactoferrin modulates immune responses, glutathione provides antioxidant protection, and prebiotics alter the nutritional landscape, collectively creating optimal conditions for probiotic colonization and effectiveness
Data Source
AI summary
The present invention relates to compositions comprising probiotic and prebiotic components, mineral salts, lactoferrin, and possibly saccharomycetes, which perform correct, effective colonisation of the probiotic components administered, with enteric consequences which involve maintaining and/or restoring intestinal health and preventing the consequences of common dysbioses of the digestive tract caused by stress, incorrect dietary habits and antibiotic treatments. Said compositions also have a concomitant anti-inflammatory and immunomodulating action.