Probiotic Composition for Memory Improvement via Gut Microbiota Modulation

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Solution Overview

Problem

Current probiotic compositions do not effectively enhance memory and learning abilities, particularly in individuals with decreased Firmicutes and Lactobacillus abundance in the gut microbiota, which is associated with cognitive disorders like Alzheimer's disease.

Innovation Solution

A probiotic composition comprising Lactobacillus acidophilus GMNL-185 and Lactobacillus rhamnosus GMNL-680, administered in a 1:1 ratio, which colonizes the gut, increases the relative abundance of Firmicutes and Lactobacillus, thereby enhancing neural activity and memory traces.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If probiotic compositions are administered to improve memory and learning ability, then cognitive function is enhanced, but the effectiveness is insufficient in individuals with decreased Firmicutes and Lactobacillus abundance

Engineering Contradiction:

Improveeffectiveness of probiotic compositionVSAvoidadaptability to different gut microbiota compositions

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies local quality by selecting specific Lactobacillus strains (L. acidophilus GMNL-185 and L. rhamnosus GMNL-680) that are adapted to colonize the gut environment and specifically target the restoration of Firmicutes and Lactobacillus populations. These strains have particular properties that enable them to effectively colonize gut epithelium and modulate the gut-brain axis, making the probiotic composition specifically effective for individuals with decreased Firmicutes and Lactobacillus abundance while maintaining adaptability to different gut microbiota compositions.

Inventive Principle:

Principle #3Local quality

2Reliability

If specific Lactobacillus strains are used to restore Firmicutes and Lactobacillus abundance, then memory and learning ability improve, but the mechanism of action is complex involving gut-brain axis

Engineering Contradiction:

Improvememory improvement effectVSAvoidcomplexity of gut-brain axis mechanism

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent employs the gut-brain axis as an intermediary mechanism, where specific Lactobacillus strains colonize the gut and produce metabolites (such as short-chain fatty acids) that signal to the brain through neural, endocrine, and immune pathways. This intermediary approach simplifies the understanding of the complex mechanism by focusing on the gut microbiota as the primary mediator that connects dietary intervention to cognitive function improvement, rather than directly targeting the brain.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If probiotic composition colonizes gut and alters microbiota composition, then neural activity and memory traces are enhanced, but the specific ratio of strains must be precisely controlled

Engineering Contradiction:

Improveneural activity enhancementVSAvoidstrain ratio control

Core Design Contradiction:

ReliabilityVSManufacturing precision

Solution Approach 1:

The patent applies parameter changes by optimizing the ratio of L. acidophilus GMNL-185 to L. rhamnosus GMNL-680 at 1:1, which has been determined to be the most effective composition for colonizing the gut and enhancing neural activity. This specific parameter optimization ensures reliable memory improvement effects while simplifying manufacturing precision requirements, as the 1:1 ratio is easier to maintain during production and storage compared to more complex multi-strain formulations.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The probiotic composition significantly improves memory and learning abilities by altering the gut microbiota, enhancing short-term and long-term memory in both young and aged fruit flies, and potentially addressing cognitive disorders.

Implementation Method 1

the probiotic composition can colonize and grow within the gut of an individual

Methodology Applied

Scientific EffectColonization:

Implementation Method 2

the probiotic composition can change the microbial composition of the individual, and increase relative abundance of Firmicutes, Lactobacillus, and Pediococcus in the gut

Methodology Applied

Scientific EffectGut microbiota modulation:

Implementation Method 3

promoting fermentation and absorption of complex carbohydrates, so as to produce short-chain fatty acids

Methodology Applied

Scientific EffectFermentation: Fermentation

Implementation Method 4

promoting productions of gamma-aminobutyric acid (neurotransmitters), serotonin, acetylcholine, histamine, short-chain fatty acids, and dopamine

Methodology Applied

Scientific EffectBiosynthesis:

Data Source

PatentUS11779616B1Method of improving memory and learning ability

Publication Date: 2023.10.10 GENMONT BIOTECH

AI summary

A probiotic composition of improving memory and learning ability is disclosed. The probiotic composition comprises Lactobacillus acidophilus GMNL-185 and Lactobacillus rhamnosus GMNL-680, wherein the Lactobacillus acidophilus GMNL-185 was deposited in the China Center for Type Culture Collection in Wuhan, China on Nov. 3, 2017 under an accession number CCTCC NO. M 2017764, and the Lactobacillus rhamnosus GMNL-680 was deposited in the China Center for Type Culture Collection in Wuhan, China on Nov. 3, 2017 under an accession number CCTCC NO. M 2017766, wherein a ratio of a number of bacteria of the Lactobacillus acidophilus GMNL-185 to a number of bacteria of the Lactobacillus rhamnosus GMNL-680 is 1:1.