Probiotic Supplementation for Offspring Immune Maturation
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Solution Overview
Problem
There is a need to enhance the immunological status of newborn offspring by targeting the immune system development during gestation and early life, as conventional nutritional measures do not effectively address the challenge of preparing the offspring for early life antigenic challenges and infectious diseases.
Innovation Solution
The use of specific probiotics such as Bifidobacterium, Lactobacillus, Streptococcus, Enterococcus, and Saccharomyces administered to expecting female mammals, either through food or dietary supplements, during gestation and lactation to boost the immune system of the offspring, potentially influencing fetal immune development and maturation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional nutritional measures are used during gestation, then the mother's general health is maintained, but the offspring's immune system development is not effectively enhanced
Solution Approach 1:
The patent changes the nutritional parameter from conventional nutrients to specific probiotic bacteria strains (Lactobacillus casei, Bifidobacterium lactis, Lactobacillus rhamnosus) administered during gestation. This parameter change transforms the nutritional intervention to specifically target immune system development in the offspring, resolving the contradiction by providing effective immune enhancement through targeted probiotic supplementation rather than general nutrition
Solution Approach 2:
The patent applies preliminary action by administering probiotics to the mother during gestation before the offspring is born. This preliminary intervention during the critical developmental period in utero prepares the offspring's immune system in advance, allowing the immune-enhancing effects to be established before exposure to antigenic challenges after birth
2Reliability
If probiotics are administered to expecting mothers, then the offspring's immune response to antigens is enhanced, but the mechanism of transmission from mother to offspring is complex
Solution Approach 1:
The patent uses the mother's immune system and breast milk as intermediaries to transmit immune-boosting effects to the offspring. The probiotics administered to the mother activate her immune system, producing cytokines and other immune mediators that are then transmitted to the offspring through breast milk during lactation, simplifying the explanation of the transmission mechanism while maintaining effective immune enhancement
Solution Approach 2:
The patent employs feedback mechanisms where the probiotic-administered mother's activated immune system produces cytokines and immune mediators that circulate back to influence fetal immune development in utero and are subsequently transmitted through breast milk. This feedback loop ensures continuous immune stimulation and maturation of the offspring's immune system during critical developmental periods
Data Source
AI summary
The present invention relates to the use of probiotic on expecting female mammals to boost the immune status of an offspring. The use can induce an enhanced response of the offspring after birth to an infectious antigenic exposure. Ultimately the use of probiotic in expecting females can induce a better protection of their offspring against infectious diseases.