Probiotic Patch for Oral Ulcer Using Localized Delivery
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Solution Overview
Problem
Existing probiotic medicaments for treating oral ulcers have limitations such as wide action sites, large dosages, low utilization rates, and inconvenient usage requiring water deprivation and fasting.
Innovation Solution
A probiotic patch prepared from a composition comprising Lactobacillus paracasei ET-22 cells and/or their extracellular metabolites, combined with sodium carboxymethyl cellulose, propolis, borneol, a lubricant, glycerol, and Tween-20, which is designed for direct application to the oral mucosa to prevent and treat oral ulcers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Area of stationary object
If traditional probiotic medicaments (oral pills, powders, capsules, tablets, granules, or sprays) are used to treat oral ulcer, then the medicament can cover wide action sites, but the dosage becomes large and the utilization rate becomes low
Solution Approach 1:
The patent applies local quality by transforming the medicament into a patch form that can be directly applied to the oral ulcer site. The patch delivers probiotics locally to the affected area, concentrating the therapeutic action where it is needed most. This localized delivery improves the utilization rate of the probiotics while reducing the overall dosage required compared to systemic administration through oral pills, powders, capsules, tablets, or granules.
2Ease of manufacture
If traditional probiotic medicaments (especially sprays) are used to treat oral ulcer, then the medicament can be administered, but water deprivation and fasting are required which creates inconvenience
Solution Approach 1:
The patent employs a disposable patch that can be directly applied to the oral ulcer site without requiring water deprivation or fasting. The patch is designed for single-use application, eliminating the need for special preparation or restrictions on the patient. This approach significantly improves usage convenience compared to traditional sprays that require water deprivation and fasting, while maintaining effective probiotic delivery to the treatment site.
3Reliability
If probiotics are used to treat oral ulcer, then the treatment can be provided, but the utilization rate of the medicament becomes low due to wide distribution
Solution Approach 1:
The patent applies segmentation by dividing the delivery system into a localized patch that targets specifically the oral ulcer site rather than distributing probiotics systemically throughout the body. This segmented approach ensures that the probiotics are concentrated where needed, improving the utilization rate and treatment effectiveness while reducing waste from wide distribution through oral administration of pills, powders, capsules, or tablets.
Data Source
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AI summary
Provided is use of Lactobacillus paracasei in preparing a medicament for preventing and treating oral ulcer. The Lactobacillus paracasei comprises Lactobacillus paracasei ET-22 cells and/or Lactobacillus paracasei ET-22 extracellular metabolites. Lactobacillus paracasei ET-22 is a strain with deposition number CGMCC No. 15077. Also provided are a probiotic composition, a method for preparing same, and use thereof. The composition comprises Lactobacillus paracasei ET-22 cells and/or Lactobacillus paracasei ET-22 extracellular metabolites, and further comprises sodium carboxymethyl cellulose, propolis, borneol, a lubricant, glycerol, and Tween-20. Further provided is a probiotic patch for preventing and treating oral ulcer, a method for preparing same, and use thereof.