Probiotic and Polyphenol Composition for Toddler Respiratory Allergy
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Solution Overview
Problem
Current treatments for respiratory allergies such as allergic rhinitis and asthma often come with adverse effects and are not suitable for long-term consumption, necessitating the development of alternative compounds that are safe and can be easily integrated into the daily diet.
Innovation Solution
A composition combining Lactobacillus paracasei and Lactococcus lactis probiotics with polyphenols, particularly epicatechin, to treat and prevent respiratory allergy symptoms, which can be administered in a form that is both effective and safe for prolonged use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If corticosteroids and anti-histaminics are used to treat respiratory allergies, then allergic symptoms are effectively treated, but adverse effects occur and chronic use is problematic
Solution Approach 1:
The patent changes the fundamental parameter of treatment approach from pharmacological intervention (corticosteroids, anti-histaminics) to nutritional intervention (probiotics and polyphenols). This shifts the mechanism of action from suppressing immune responses to modulating immune system development and function through dietary components, thereby eliminating adverse effects while maintaining treatment efficacy
Solution Approach 2:
The patent employs food-grade probiotics and polyphenols that can be consumed through diet rather than requiring prescription medications. These nutritional components are safe for long-term use, can be obtained from everyday foods, and do not carry the same risks as chronic pharmaceutical use, making them a sustainable alternative for managing respiratory allergies
2Object-affected harmful factors
If probiotics and polyphenols are used as nutritional interventions, then safety for prolonged consumption is improved, but the efficacy compared to medications needs to be demonstrated
Solution Approach 1:
The patent combines two distinct nutritional components - probiotics (Lactobacillus paracasei and Lactococcus lactis) and polyphenols (particularly epicatechin) - into a synergistic formulation. This combination approach merges the immune-modulating effects of probiotics with the anti-inflammatory and antioxidant properties of polyphenols, thereby enhancing overall efficacy while maintaining safety for prolonged consumption
3Reliability
If specific probiotic strains are used alone, then immune system benefits are provided, but comprehensive anti-allergic effects are not achieved
Solution Approach 1:
The patent creates a composite nutritional formulation that integrates probiotic bacteria with polyphenolic compounds. This composite approach combines the immunomodulatory capabilities of probiotics with the antioxidant and anti-inflammatory properties of polyphenols, providing comprehensive anti-allergic effects that address multiple aspects of allergic pathology including immune system modulation, oxidative stress reduction, and inflammation control
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination effectively reduces symptoms of respiratory allergies, including ocular and sleep disorders, improving quality of life and mood swings, while being free from adverse effects and easily consumable as part of a daily diet.
Implementation Method 1
probabilistic bacteria (Kalliomaki et al., Lancet. 2001, 357:1076-9), prebiotics (Arslanoglu et al. 2008, J Nutr 138:1091-1095) and poly-unsaturated fatty acids (Dunstan et al. 2003, J Allergy Clin Immunol 112: 1178-1184) have been documented
Implementation Method 2
Dietary polyphenols and polyphenol rich plant materials have also been studied extensively in numerous disease models and published data suggest that their presence may have an important role in preventing tissue damage due to oxidative stress
Implementation Method 3
They can promote good digestion, boost the immune system, and produce lactic and acetic acid that controls intestinal pH
Data Source
AI summary
The present invention relates to a composition for use in the prevention of respiratory allergy, in particular allergic rhinitis, dust mite allergy and/or asthma in toddlers. The invention also provides a kit comprising a combination of at least one polyphenol and at least one probiotic selected from the group consisting of Lactobacillus paracasei and Lactococcus lactis in one or more containers.